3 documents found, page 1 of 1
Neuronal cell-based high-throughput screen for enhancers of mitochondrial funct...
Naia, Luana Carvalho; Pinho, Catarina M.; Dentoni, Giacomo; Liu, Jianping; Leal, Nuno Santos; Ferreira, Duarte M. S.; Schreiner, BernadetteBackground: Mitochondrial dysfunction is a common feature of aging, neurodegeneration, and metabolic diseases. Hence, mitotherapeutics may be valuable disease modifiers for a large number of conditions. In this study, we have set up a large-scale screening platform for mitochondrial-based modulators with promising therapeutic potential. Results: Using differentiated human neuroblastoma cells, we screened 1200 F...
Role of lysine deacetylases on transcription regulation and mitochondrial funct...
Naia, Luana CarvalhoTese de doutoramento em Ciências da Saúde, ramo Ciências Biomédicas apresentada à Faculdade de Medicina da Universidade de Coimbra; Huntington’s disease (HD) is a neurodegenerative disorder that gradually affects memory, cognitive skills and normal movements of the affected individuals and for which no disease modifying treatments exist. The disease is caused by an expanded CAG trinucleotide repeat (of variable...
Role of Insulin and Igf-1 in Energy Metabolism in Huntington’s Disease: Studies...
Naia, Luana CarvalhoA doença de Huntington (HD) é uma doença autossómica neurodegenerativa progressiva, caracterizada pela perda de coordenação motora, défice cognitivo e distúrbios psiquiátricos, afectando cerca de um em cada 100,000 indivíduos. A HD envolve uma perda selectiva dos neurónios espinhosos médios do estriado, como consequência de uma repetição da expansão de trinucleótido CAG (que codifica para glutamina) na proteína...