18 documents found, page 1 of 2

In vitro evaluation of antileishmanial activity of copper (I) complexes

In the research for the development of new drugs for the therapy of American tegumentary leishmaniasis, copper has been studied for its antileishmania activity. This study aims to report the activity of three copper(I) complexes on parasites of the species L. amazonensis and L. guyanensis. The metal complexes were tested according to in vitro antileishmanial assays, against promastigote and amastigote forms of ...

Recent advances in the taxonomy of the New World leishmanial parasites

Genetic polymorphism and molecular epidemiology of Leishmania (Viannia) brazili...

Numerical zymotaxonomy and variability of the internal transcribed spacers (ITS) between the small and large subunits of the rRNA genes were used to examine strain variation and relationships in natural populations of Leishmania (Viannia) braziliensis. A total of 101 strains from distinct hosts and Brazilian geographic regions were assigned to 15 zymodemes clustered in two major genetic groups. The great number...

Evaluation of different diagnostic methods of American Cutaneous Leishmaniasis ...

Epidemiological studies have been conducted to better understand the dynamics of American Cutaneous Leishmaniasis (ACL) in the Amazon region where distinct species of Leishmania circulate. In endemic areas, the optimal diagnosis must be made in the earlier clinical presentation to avoid the complications of chronic disease. The scarcity of financial support, laboratory infrastructure and trained persons are the...

Antimicrobial and Larvicidal Activities of Stingless Bee Pollen from Maues, Ama...

Estudo de uma série de casos de Leishmaniose Tegumentar Americana o municipio d...

The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patien...

The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species of Leishmania in Amazonas State, Brazil. A comparative analysis was made of serum concentrations of these cytokines in the peripheral blood of 33 patients infected with cutaneous leishmaniasis. The isolates were identified as Leishmania guyanensis, L. naiffi, and L....

Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Me...

Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamste...

Encuesta epidemiologica de histoplasmosis, paracoccidioidomycosis y leishmanias...

Estudo de uma série de casos deleishmaniose tegumentar americana no município d...