369 documents found, page 1 of 37
Development of antimicrobial peptide-loaded hydrogels as potential scaffolds fo...
Noohi, Parisa; Abdekhodaie, Mohammad J.; Nekoofar, Mohammad H.; Gama, F. M.; Saadatmand, Maryam; Dummer, Paul M. H.Introduction: As a recently developed treatment modality, regeneration of the pulp-dentin-like complex via tissue engineering approaches is the focus of considerable attention. The persistence of bacteria within the root canal spaces is well known as the major challenge of dental pulp regeneration. Antimicrobial peptides (AMPs) are short peptides with inhibitory activities against a broad spectrum of microorgan...
Optimizing bacterial nanocellulose production from eucalyptus bark: a circular ...
Rodrigues, Ana Cristina Costa; Martins, Daniela Sofia Rodrigues; Duarte, Maria Salomé Lira; Carvalho, Ricardo Emanuel Silva; Marques, SusanaThe production cost of bacterial nanocellulose (BNC) is a major limitation to its widespread use. However, this limitation can be addressed by using alternative low-cost substrates and high-yield strains. Agro-industrial waste-derived substrates offer a cost-effective and sustainable solution, but their high organic load often requires additional downstream wastewater treatments. Here, we optimized static BNC p...
Life cycle assessment of bacterial cellulose and comparison to other cellulosic...
Soares da Silva, F. A. G.; Branco, Sara; Dourado, Fernando; Neto, Belmira; Gama, F. M.Bacterial cellulose (BC) is a 3D exopolysaccharide synthesized by certain acetic acid bacteria, possessing unique properties such as nanofibrillar morphology and high purity. BC has gained increasing attention for several potential market applications, including in textiles. However, along with techno-economic challenges, the industrialization of BC pulp must align with sustainable practices and minimize the en...
Laser‑patterning bacterial nanocellulose for cell‑controlled interaction
Costa, Lígia; Carvalho, Alexandre F.; Carvalho, Ricardo Emanuel Silva; Rodrigues, Ana Cristina; Dourado, Fernando; Deuermeier, Jonas; Neto, Miguel A.The interfacial topography of biomaterials has been identified as a major biophysical regulator of cell behavior and function, a role played through the interplay with biochemical cues. In this work, we demonstrate the potential of laser as a versatile technology for the direct fine-tuning of the topography of Bacterial nanocellulose (BNC) with bioinspired topographies and micropatterns on a cell size scale. Tw...
Enhanced bacterial cellulose production in komagataeibacter sucrofermentans: im...
Silva, Pedro Moreira Montenegro Baptista; Ellis, Tom; Dourado, Fernando; Gama, F. M.; Domingues, LucíliaBackground Bacterial cellulose (BC) is a biocompatible material with unique mechanical properties, thus holding a significant industrial potential. Despite many acetic acid bacteria (AAB) being BC overproducers, cost-effective production remains a challenge. The role of pyrroloquinoline quinone (PQQ)-dependent membrane dehydrogenases (mDH) is crucial in the metabolism of AAB since it links substrate incomplete ...
Bacterial cellulose in vitro uptake by macrophages, epithelial cells, and a tri...
Carvalho, Ricardo Emanuel Silva; Rodrigues, Patrícia M.; Martins, Daniela Sofia Rodrigues; Rodrigues, Ana Cristina Costa; Sampaio, PaulaBacterial cellulose (BC) has a long-standing human consumption history in different geographies without any report of adverse effects. Despite its unique textural and functional properties, the use of BC in food products in Europe is still restricted due to concerns over its nanosize. Here, we evaluated the potential uptake of celluloses (from plant and microbial sources, processed using different blenders) by ...
Development of a dextrin-vitamin D3 micelle nanocarrier for the antimicrobial p...
Machado, Fátima Alexandra Meira; Gama, F. M.; Martins, J. A. R.In this work, an expedite synthesis was developed for a self-assembled micelle carrier for the antimicrobial peptide LL18. Covalent one-pot functionalization of dextrin with succinylated vitamin D3 and succinic anhydride produced an amphiphilic material that undergoes self-assembly into micelles in aqueous medium. Succinylated dextrinvitamin D3 micelles were efficiently loaded with LL18 by electrostatic and hyd...
Vitamin D loaded into lipid nanoparticles shows insulinotropic effect in INS-1E...
Cristelo, Cecília Silva; Sá, Ana Filipa Amorim; Lúcio, Marlene; Sarmento, Bruno; Gama, F. M.Increasing evidence suggests a beneficial role of vitamin D (VitD) supplementation in addressing the widespread VitD deficiency, but currently used VitD3 formulations present low bioavailability and toxicity constrains. Hence, poly(L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), solid-lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were investigated to circumvent these issues. PLGA NPs p...
Effect of bacterial cellulose on the foaming properties of egg white and soy pr...
Martins, Daniela Sofia Rodrigues; Khodamoradi, Niloofar; Carvalho, Ricardo Emanuel Silva; Gama, F. M.; Moradi, Mehran; Dourado, FernandoFood foams are highly industrially relevant systems, responsible for the visual appearance and organoleptic properties of many processed foods. Foam characteristics can be further improved by food-grade additives. This study investigates the influence of bacterial cellulose (BC) on the foaming capacity (FC) and foam stability (FS) of egg white protein (EWP) and soy protein isolate (SPI), important food foaming ...
Upcycling of cellulosic textile waste with bacterial cellulose via Ioncell® tec...
Schlapp-Hackl, Inge; Nygren, Nicole; Heimala, Senni; Leinonen, Anna; Dourado, Fernando; Gama, F. M.; Hummel, Michael; Silva, Francisco A.G.S.Currently the textile industry relies strongly on synthetic fibres and cotton, which contribute to many environmental problems. Man-made cellulosic fibres (MMCF) can offer sustainable alternatives. Herein, the development of Lyocell-type MMCF using bacterial cellulose (BC) as alternative raw material in the Ioncell® spinning process was investigated. BC, known for its high degree of polymerization (DP), crystal...