2 documents found, page 1 of 1
A next-generation liquid xenon observatory for dark matter and neutrino physics
Aalbers, J.; AbdusSalam, S. S.; Abe, K.; Aerne, V.; Agostini, F.; Ahmed Maouloud, S.; Akerib, D. S.; Akimov, D. Y.; Akshat, J.; Al Musalhi, A. K.The nature of dark matter and properties of neutrinos are among the most pressing issues in contemporary particle physics. The dual-phase xenon timeprojection chamber is the leading technology to cover the available parameter space for weakly interacting massive particles, while featuring extensive sensitivity to many alternative dark matter candidates. These detectors can also study neutrinos through neutrinol...
Nucleic acid oxidation in Alzheimer disease
Moreira, Paula I.; Nunomura, Akihiko; Nakamura, Masao; Takeda, Atsushi; Shenk, Justin C.; Aliev, Gjumrakch; Smith, Mark A.; Perry, GeorgeIncreasing evidence suggests that oxidative stress is intimately associated with Alzheimer disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are one of the several cellular macromolecules damaged by reactive oxygen species, particularly the hydroxyl radical. Because neurons are irreplaceable and survive as long as the organism does, they need elaborate defense mechanisms to ensure...