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Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definiti...

Sato,Douglas Kazutoshi; Callegaro,Dagoberto; Lana-Peixoto,Marco Aurélio; Nakashima,Ichiro; Fujihara,Kazuo

Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cell-based assays....

Date: 2014   |   Origin: Oasisbr
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