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Characterization and evaluation of the enzymatic activity of tetanus toxin subm...
Sartori,Giselle Pacifico; Costa,Andréa da; Macarini,Fernanda Lúcio dos Santos; Mariano,Douglas Oscar Ceolin; Pimenta,Daniel CarvalhoAbstract Background Tetanus toxin blocks the release of the inhibitory neurotransmitters in the central nervous system and causes tetanus and its main form of prevention is through vaccination. The vaccine is produced by inactivation of tetanus toxin with formaldehyde, which may cause side effects. An alternative way is the use of ionizing radiation for inactivation of the toxin and also to improve the potentia...
Natalizumab treatment for multiple sclerosis: updates and considerations for sa...
Nali,Luiz Henrique da Silva; Moraes,Lenira; Fink,Maria Cristina Domingues; Callegaro,Dagoberto; Romano,Camila Malta; Oliveira,Augusto Cesar Penalva deNatalizumab is currently one of the best options for treatment of patients with Multiple Sclerosis who have failed traditional prior therapies. However, prolonged use, prior immunosuppressive therapy and anti-JCV antibody status have been associated with increased risk of developing progressive multifocal leukoencephalopathy (PML). The evaluation of these conditions has been used to estimate risks of PML in the...