3 documents found, page 1 of 1
Stanozolol induces ventricular dysfunction by decreasing phospholamban phosphor...
Andrade, Tadeu Uggere de; Dubois Fillho, Dionisio; Silva, Cristiane Lyrio da; Silva, Mirian de Almeida; Almeida, Simone Alves deStanozolol is a steroid that causes lipid deposition in LDLr-/- mice, although the mechanism by which this dyslipidemia results in cardiac dysfunction is little understood. The aim of this study was to evaluate the effect of stanozolol on cardiac contractility and the participation of myocardial phospholamban (pPLB) phosphorylation in an atherosclerosis mouse model. LDL receptor knockout mice (LDLr-/-) were fed...
Finasteride promotes worsening of the cardiac deleterious effects of nandrolone...
Mata, Elizângela Faustino Da; Nascimento, Andrews Marques do; Lima, Ewelyne Miranda de; Kalil, Ieda Carneiro; Endringer, Denise Coutinho; Lenz, DominikMetabolism of anabolic androgenic steroids is important for its physiological effects. The aim was to investigate the effects of finasteride (a 5α-reductase inhibitor - 5αR) on cardiac and mutagenic effects promoted by ND. Male Wistar rats were separated into three groups: CONT, received the vehicles of ND and finasteride (Peanut oil+Saline); DECA group, received ND (20 mg.kg.week-1, i.m.), and DECAF received N...
Hypotensive effect and endothelium-dependent vascular action of leaves of Alpin...
Silva, Alessandra Tesch da; Lima, Ewelyne Miranda de; Caliman, Isabela Faco; Porto, Leonardo Luiz Souza; Nascimento, Andrews Marques doOs objetivos deste estudo foram avaliar o perfil químico de folhas de Alpinia purpurata K. Schum (AP), assim como a reatividade vascular e o efeito hipotensor agudo (EHA) do extrato etanólico de folhas de AP (EEAP). Avliou-se o perfil químico utilizando-se HPLC-UV, ICP-OES e quantificação colorimétrica de flavonoides e polifenóis totais. A reatividade vascular foi determinada utilizando leito mesentérico isolad...