20 documents found, page 1 of 2
Prediction of Hepatocellular Carcinoma in a Portuguese Population after Hepatit...
Mascarenhas, André; Serrazina, Juliana; Bronze, Sérgio; Cortez-Pinto, Helena; Presa, José; Barreira, Ana; Carrola, Paulo; Vara-Luiz, FranciscoIntroduction: Chronic infection with hepatitis C virus (HCV) causes 25% of hepatocellular carcinoma (HCC) cases worldwide, a major cause of morbimortality even after sustained virologic response (SVR). Universal screening to all patients with advanced liver fibrosis is currently recommended. A risk-based strategy could improve the detection rate of early HCC and diminish the surveillance burden. Although severa...
HER2-Targeted immunotherapy and combined protocols showed promising antiprolife...
Gameiro, Andreia; Nascimento, Catarina; Correia, Jorge Manuel de Jesus; Ferreira, FernandoABSTRACT - Feline mammary carcinoma (FMC) is a highly prevalent tumor, showing aggressive clinicopathological features, with HER2-positive being the most frequent subtype. While, in human breast cancer, the use of anti-HER2 monoclonal antibodies (mAbs) is common, acting by blocking the extracellular domain (ECD) of the HER2 protein and by inducing cell apoptosis, scarce information is available on use these imm...
Serum and tissue expression levels of leptin and leptin receptor are putative m...
Gameiro, Andreia; Nascimento, Catarina; Urbano, Ana Catarina; Correia, Jorge Manuel de Jesus; Ferreira, FernandoABSTRACT - Obesity is an established risk factor for breast cancer in post-menopausal women, being associated with elevated serum levels of leptin. Although overweight is a common condition in cat, the role of leptin and its receptor in feline mammary carcinoma remains unsettled. In this study, serum leptin and leptin receptor (ObR) levels were investigated in 58 cats with mammary carcinoma and compared with th...
Inflammatory Bowel Disease patients’ perspectives during COVID-19 pandemic: res...
Revés, Joana Branco; Frias-Gomes, Catarina; Morão, Bárbara; Nascimento, Catarina; Palmela, Carolina; Fidalgo, Catarina; Roque Ramos, Lídia; Sampaio, AnaIntroduction: Patients with inflammatory bowel disease (IBD) do not seem to be at increased risk of infection by SARS-CoV-2, but there is a concern whether immunosuppressive therapy may be associated with more severe disease. Several clinical practice recommendations have been published to help guide IBD care during the COVID-19 pandemic. Nonetheless, few studies have addressed patients' perspectives and fears....
Tyrosine kinase inhibitors are promising therapeutic tools for cats with HER2-p...
Gameiro, Andreia; Almeida, Filipe; Nascimento, Catarina; Correia, Jorge Manuel de Jesus; Ferreira, FernandoABSTRACT - Feline mammary carcinoma (FMC) is a common neoplasia in cat, being HER2-positive the most prevalent subtype. In woman’s breast cancer, tyrosine kinase inhibitors (TKi) are used as a therapeutic option, by blocking the phosphorylation of the HER2 tyrosine kinase domain. Moreover, clinical trials demonstrated that TKi produce synergistic antiproliferative effects in combination with mTOR inhibitors, ov...
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma
Nascimento, Catarina; Gameiro, Andreia; Ferreira, Fernando; Correia, Jorge Manuel de Jesus; Ferreira, JoãoVascular endothelial growth factor (VEGF-A) plays an essential role in tumor-associated angiogenesis, exerting its biological activity by binding and activating membrane receptors, as vascular endothelial growth factor receptor 1 and 2 (VEGFR-1, VEGFR-2). In this study, serum VEGF-A, VEGFR1, and VEGFR-2 levels were quantified in 50 cats with mammary carcinoma and 14 healthy controls. The expression of these mol...
VISTA is a diagnostic biomarker and immunotherapy target of aggressive feline m...
Gameiro, Andreia; Nascimento, Catarina; Correia, Jorge; Ferreira, FernandoABSTRACT - Feline mammary carcinoma (FMC) is a common neoplasia, showing aggressive clinicopathological features, without viable therapeutic options. The study of tumor microenvironment has gained importance, due to the ability to control tumor progression by regulating the immune response. Considering the lack of knowledge, feline serum VISTA levels from cats with mammary carcinoma were compared with healthy c...
Anaplastic mammary carcinoma in cat
Soares, Maria; Correia, Jorge Manuel de Jesus; Nascimento, Catarina; Ferreira, FernandoClinical, pathological, and immunohistochemical findings related to a feline mammary tumor with similar features to canine anaplastic mammary carcinoma are herein described for the first time. A female cat was presented for clinical evaluation with gastrointestinal signs, oedema, erythema, and painful lesion in the right inguinal region. Three weeks later, the mass had doubled in size and radiographic revaluati...
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline mammary carcinoma
Nascimento, Catarina; Gameiro, Andreia; Ferreira, João; Correia, Jorge; Ferreira, FernandoVascular endothelial growth factor (VEGF-A) plays an essential role in tumor-associated angiogenesis, exerting its biological activity by binding and activating membrane receptors, as vascular endothelial growth factor receptor 1 and 2 (VEGFR-1, VEGFR-2). In this study, serum VEGF-A, VEGFR-1, and VEGFR-2 levels were quantified in 50 cats with mammary carcinoma and 14 healthy controls. The expression of these mo...
Serum PD-1/PD-L1 levels, tumor expression and PD-L1 somatic mutations in HER2-p...
Nascimento, Catarina; Urbano, Ana Catarina; Gameiro, Andreia; Ferreira, João; Correia, Jorge Manuel de Jesus; Ferreira, FernandoTumor microenvironment has gained great relevance due to its ability to regulate distinct checkpoints mediators, orchestrating tumor progression. Serum programmed cell death protein-1 (PD-1) and programmed death ligand-1 (PD-L1) levels were compared with healthy controls and with serum cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and tumor necrosis factor-alpha (TNF-α) levels in order to understand the ...