4 documents found, page 1 of 1
Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic applica...
Nascimento, Demétrius Fernandes do; Moraes Filho, Manoel Odorico de; Bezerra, Fernando Antônio Frota; Pontes, Andréa Vieira; Uchoa, Célia Regina AmaralTo develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS). The analyte and IS were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1 v/v). The chromatographic separation was performed on a Varian ® Polaris C18 analytical column (3 m m, 50 x 2.0 mm) and pre-column Securityguard...
Determinação de nimodipino em plasma humano através de cromatografia líquida de...
Nascimento, Demétrius Fernandes doA rapid, specific and highly sensitive liquid chromatography-tandem mass spectrometry method was developed to determine nimodipine in human plasma using dibucaine as the internal standard (IS) is described. The analyte (m/z 418,6 > 342,6) and IS (m/z 344,2 > 271,0) were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1v/v). Chromatography was performed on a Varian® Polari...
Quantificação de fármacos com atividade antimicrobiana em plasma humano por cro...
Nascimento, Demétrius Fernandes doTwo robust, fast and sensitive methods for quantification of sulfamethoxazole (SMX), trimethoprim (TMP) and sulfadiazine (SDZ) in plasma using high performance liquid chromatography coupled to mass spectrometry (LC-MS/MS) was developed and validated. The methods involved liquid-liquid extraction with ethyl acetate using metoprolol and sulfamethoxazole as internal standards (PI). The chromatographic separations ...
Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic applica...
Nascimento, Demétrius Fernandes do; Moraes, Manoel Odorico de; Bezerra, Fernando Antônio Frota; Pontes, Andréa Vieira; Uchoa, Célia Regina AmaralTo develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS). The analyte and IS were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1 v/v). The chromatographic separation was performed on a Varian® Polaris C18 analytical column (3 μm, 50 x 2.0 mm) and pre-column Securitygu...