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The use of the anticoagulant heparin and corticosteroid dexamethasone as promin...
Melo, Heloísa Antoniella Braz de; Faria, Sara Socorro; Nascimento, Gabriel Pasquarelli do; Santos, Igor de Oliveira; Kobinger, Gary P.COVID-19 is spreading worldwide at disturbing rates, overwhelming global healthcare. Mounting death cases due to disease complications highlight the necessity of describing efficient drug therapy strategies for severe patients. COVID-19 severity associates with hypercoagulation and exacerbated inflammation, both influenced by ACE2 downregulation and cytokine storm occurrence. In this review, we discuss the appl...
Potential neuroprotective and antiinfammatory efects provided by omega-3 (DHA) ...
Melo, Heloísa Antoniella Braz de; Nascimento, Gabriel Pasquarelli do; Corrêa, Rafael; Almeida, Raquel das Neves; Santos, Igor de OliveiraZika virus (ZIKV) has a strong tropism for the nervous system and has been related to post-infection neurological syndromes. Once neuronal cells are infected, the virus is capable of modulating cell metabolism, leading to neurotoxicity and cellular death. The negative efect of ZIKV in neuron cells has been characterized. However, the description of molecules capable of reversing these cytotoxic efects is still ...
Hypercoagulopathy and adipose tissue exacerbated inflammation may explain highe...
Nascimento, Gabriel Pasquarelli do; Melo, Heloísa Antoniella Braz de; Faria, Sara Socorro; Santos, Igor de Oliveira; Kobinger, Gary P.COVID-19, caused by SARS-CoV-2, is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Several reports from around the world have identified obesity and severe obesity as one of the strongest risk factors for COVID-19 hospitalization and mechanical ventilation. Moreover, countries with greater obesity prevalence have a higher morbidity and mortality risk of developing serious ou...
Análise da modulação de parâmetros carcinogênicos de células de câncer de ovári...
Nascimento, Gabriel Pasquarelli doDissertação (mestrado)—Universidade de Brasília, Departamento de Biologia Celular, Programa de Pós-Graduação em Biologia Molecular, 2018.; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ) e Fundação de Apoio à Pesquisa do Distrito Federal (FAP-DF).; O ácido docosahexaenoico (DHA) é um ácido graxo da família dos Ômega-3 obtido principalmente a partir do óleo de peixe. O consumo em quantidades...