3 documents found, page 1 of 1
Triterpenes from minquartia guianensis (olacaceae) and in vitro antimalarial ac...
Cursino, Lorena Mayara de Carvalho; Nunez, C. V.; Paula, Renata Cristina de; Nascimento, Maria Fernanda Alves do; dos Santos, Pierre Alexandre LexandreMinquartia guianensis, popularly known as acariquara, was phytochemically investigated. The following triterpenes were isolated from the dichloromethane extract of leaves: lupen-3-one (1), taraxer-3-one (2) and oleanolic acid (3). The dichloromethane extract of branches yielded the triterpene 3β-methoxy-lup-20(29)-ene (4). The chemical structures were characterized by NMR data. Plant extracts, substance 3, squa...
Synthesis by click reactions and antiplasmodial activity of Lupeol 1,2,3-Triazo...
Borgati, Tatiane Freitas; Pereira, Guilherme Rocha; Brandão, Geraldo Célio; Santos, Juliana de Oliveira; Fernandes, Dayane Aparecida MoraisLupeol, a triterpene frequently found in Asteraceae plant species, showed moderate to low activity in different strains of Plasmodium falciparum, the most virulent malaria etiological agents. In this work, lupeol was isolated from Parahancornia fasciculata, a plant that is used to treat malaria in the Amazonia region. In the search of more activity lupeol derivatives, five new 1,2,3-triazole hybrid molecules we...
Spleen cell proliferation during and after skin myiasis by human bot fly Dermat...
Gonçalves, Jomara Mendes; Nascimento, Maria Fernanda Alves do; Breyner, Natália Martins; Fernandes, Viviane Cristina; Góes, Alfredo Miranda deSpleen cells from mice were examined at 5, 10, 15, 20 and 25 days post-infection (dpi) with Dermatobia hominis larva and at 5, 10, 15, 30 and 60 days post-larval emergence (dple). Cell proliferation in vitro assays were carried out with RPMI-1640 medium and larval secretory product (LSP) of D. hominis at 5, 10, 15, 20 and 25 days. When each group of mice was tested against each medium, significance was only see...