3 documents found, page 1 of 1
Emerging Chagas Disease : trophic network and cycle of transmission of Trypanos...
Teixeira, Antonio Raimundo Lima Cruz; Monteiro, Pedro Sadi; Rebêlo, José Manuel Macário; Argañaraz, Enrique Roberto; Vieira, DanielaABSTRACT; A trophic network involving molds, invertebrates, and vertebrates, ancestrally adapted to the palm tree (Attalaea phalerata) microhabitat, maintains enzootic Trypanosoma cruzi infections in the Amazonian county Paço do Lumiar, state of Maranhão, Brazil. We assessed seropositivity for T. cruzi infections in the human population of the county, searched in palm trees for the triatomines that harbor these...
Hitchhiking Trypanosoma cruzi minicircle DNA affects gene expression in human h...
Barbosa, Augusto Mello Simões; Argañaraz, Enrique Roberto; Costa, Ana Maria; Rosa, Ana de Cassia Oliveira Cardoso; Alves, Nivaldo PereiraThe horizontal transfer of Trypanosoma cruzi mitochondrial minicircle DNA to the genomes of naturally infected humans may play an important role in the pathogenesis of Chagas disease. Minicircle integrations within LINE-1 elements create the potential for foreign DNA mobility within the host genome via the machinery associated with this retrotransposon. Here we document integration of minicircle DNA fragments i...
Persistent infections in chronic Chagas’ disease patients treated with anti-Try...
Braga, Maria do Socorro Costa Oliveira; Pires, Liana Lauria; Argañaraz, Enrique Roberto; Nascimento, Rubens José doUsamos um método molecular e demonstramos que o tratamento de infecções crônicas pelo Trypanosoma cruzi com nitroderivados, que se mostraram eficientes em diminuir parasitemias nas infecções agudas, não produziu cura parasitológica. Trinta e quatro chagásicos crônicos, com pelo menos dois entre três testes sorológicos positivos para a infecção, e 17 controles com testes sorológicos negativos formaram os grupos ...