6 documents found, page 1 of 1
Intramedullary nailing biomechanics: Evolution and challenges
Natacha Rosa; Miguel Marta; Mário Vaz; Sérgio M. O. Tavares; Ricardo Simões; Fernão D. Magalhães; António Torres MarquesThis article aims to review the biomechanical evolution of intramedullary nailing and describe the breakthrough concepts which allowed for nail improvement and its current success. The understanding of this field establishes an adequate background for forthcoming research and allows to infer on the path for future developments on intramedullary nailing. It was not until the 1940s, with the revolutionary Kuntsch...
Recent developments on intramedullary nailing: a biomechanical perspective
António Torres Marques; Natacha Rosa; Magalhães, F. D.; Mário Vaz; Sérgio Tavares; Ricardo Simões; Miguel MartaCombining contributions from engineering and medicine, we highlight the biomechanical turning points in the historical evolution of the intramedullary nailing stabilization technique and discuss the recent innovations concerning increase in bone-implant system stability. Following the earliest attempts, where stabilization of long bone fractures was purely based on intuition, intramedullary nailing evolved from...
From mechanical stimulus to bone formation: A review
Natacha Rosa; Ricardo Simões; Fernão D. Magalhães; António Torres MarquesBone is a remarkable tissue that can respond to external stimuli. The importance of mechanical forces on the mass and structural development of bone has long been accepted. This adaptation behaviour is very complex and involves multidisciplinary concepts, and significant progress has recently been made in understanding this process. In this review, we describe the state of the art studies in this area and highl...
Preparation of robust polyamide microcapsules by interfacial polycondensation o...
Natacha Rosa; G. V. Martins; Margarida M. S. M. Bastos; J. R. Góis; J.F. J. Coelho; J. Marques; C. J. Tavares; F. D. MagalhãesMicrocapsules produced by interfacial polycondensation of p-phenylenediamine (PPD) and sebacoyl chloride (SC) were studied. The products were characterized in terms of morphology, mean diameter and effectiveness of dodecane encapsulation. The use of Tween 20 as dispersion stabilizer, in comparison with polyvinyl alcohol (PVA), reduced considerably the mean diameter of the microcapsules and originated smoother w...
Predicting the secondary structure of proteins using Machine Learning algorithms
Nuno Fonseca; Vítor Santos Costa; Alexandre Magalhães; Miguel de Sousa; Vânia Guimarães; Natacha Rosa; Rui Camacho; Rita FerreiraThe functions of proteins in living organisms are related to their 3-D structure, which is known to be ultimately determined by their linear sequence of amino acids that together form these macromolecules. It is, therefore, of great importance to be able to understand and predict how the protein 3D- structure arises from a particular linear sequence of amino acids. In this paper we report the application of Mac...
Predicting the secondary structure of proteins using Machine Learning algorithms
Rui Camacho; Rita Ferreira; Natacha Rosa; Vânia Guimarães; Nuno A Fonseca; Vítor Santos Costa; Miguel de Sousa; Alexandre MagalhaesThe functions of proteins in living organisms are related to their 3-D structure, which is known to be ultimately determined by their linear sequence of amino acids that together form these macromolecules. It is, therefore, of great importance to be able to understand and predict how the protein 3D-structure arises from a particular linear sequence of amino acids. In this paper we report the application of Mach...