3 documents found, page 1 of 1
Swim training attenuates the adverse remodeling of LV structural and mechanical...
Locatelli, Jamille; Paiva, Nívia C.N.; Carvalho, Sara H.R.; Lavorato, Victor N.; Gomes, Luis Henrique L.S.; Castro, Quênia J.T.; Grabe-Guimarães, AndreaInvestigate to what extent low-intensity swim training for six weeks counterbalances the adverse remodeling due to the advance of pathological hypertrophy in the left ventricle (LV) structural and mechanical properties in the early compensated phase of hypertension in male SHR. Four-month-old male SHR and Wistar rats were randomly divided into Sed (sedentary) and Ex (exercised) groups. The exercised rats were s...
Attenuation of Ca2+ homeostasis, oxidative stress, and mitochondrial dysfunctio...
Natali, Antônio J.; Silva, Márcia F. da; Silva, Edson da; Gomes, Gilton J.; Teodoro, Bruno G.; Cunha, Daise N. Q.; Drummond, Lucas R.We tested the effects of swimming training and insulin therapy, either alone or in combination, on the intracellular calcium ([Ca2+]i) homeostasis, oxidative stress, and mitochondrial functions in diabetic rat hearts. Male Wistar rats were separated into control, diabetic, or diabetic plus insulin groups. Type 1 diabetes mellitus was induced by streptozotocin (STZ). Insulin-treated groups received 1 to 4 UI of ...
Enalapril in combination with benznidazole reduces cardiac inflammation and cre...
Penitente, Arlete Rita; Leite, Ana Luísa Junqueira; Costa, Guilherme de Paula; Shrestha, Deena; Horta, Aline Luciano; Natali, Antônio J.The protozoan Trypanosoma cruzi triggers an inflammatory process in mammalian heart causing events such as fibrosis, changes in the architecture and functionality in this organ. Enalapril, an angiotensin II-converting enzyme inhibitor, is a drug prescribed to ameliorate this heart dysfunction, and appears to exert a potential role in immune system regulation. Our aim was to evaluate the chronic cardiac inflamma...