21 documents found, page 1 of 3
Molecular and cellular biomarkers of COVID-19 prognosis : protocol for the pros...
Kurizky, Patricia Shu; Nóbrega, Otávio T.; Soares, Alexandre Anderson de Sousa Munhoz; Aires, Rodrigo Barbosa; Albuquerque, Cleandro Pires deBackground: Since the beginning of the COVID-19 pandemic, the world’s attention has been focused on better understanding the relation between the human host and the SARS-CoV-2 virus, as its action has led to hundreds of thousands of deaths. Objective: In this context, we decided to study certain consequences of the abundant cytokine release over the innate and adaptive immune systems, inflammation, and hemostas...
SARS-CoV-2/DENV co-infection : a series of cases from the Federal District, Mid...
Schulte, Heidi Luise; Sousa, José Diego Brito; Lacerda, Marcus Vinícius Guimarães de; Naves, Luciana Ansaneli; Gois, Eliana Teles deBackground: Since the novel coronavirus disease outbreak, over 179.7 million people have been infected by SARS-CoV-2 worldwide, including the population living in dengue-endemic regions, particularly Latin America and Southeast Asia, raising concern about the impact of possible co-infections. Methods: Thirteen SARS-CoV-2/DENV co-infection cases reported in Midwestern Brazil between April and September of 2020 a...
Brazilian multicenter study on pegvisomant treatment in acromegaly
Boguszewski, Cesar L.; Huayllas, Martha Katherine P; Vilar, Lucio; Naves, Luciana Ansaneli; Ribeiro-Oliveira Junior, Antonio; Soares, Beatriz SantanaObjective Investigate the therapeutic response of acromegaly patients to pegvisomant (PEGV) in a real-life, Brazilian multicenter study. Subjects and methods Characteristics of acromegaly patients treated with PEGV were reviewed at diagnosis, just before and during treatment. All patients with at least two IGF-I measurements on PEGV were included. Efficacy was defined as any normal IGF-I measurement during trea...
Transient elastography and controlled attenuation parameter (CAP) in the assess...
Furtado, Adriana Claudia Lopes Carvalho; Louro, Daniela Mariano Carvalho; Regattieri, Neysa Aparecida Tinoco; Rodrigues, Marcelo PalmeiraNon-alcoholic fatty liver disease (NAFLD) is common in patients with growth hormone deficiency (GHD). Some noninvasive techniques have been used to quantify liver fat, such as the controlled attenuation parameter (CAP). Objective: To evaluate CAP as a tool to identify liver steatosis and its relationship with different clinical and biochemical metabolic parameters in a group of patients with severe adult growth...
Controversial issues in the management of hyperprolactinemia and prolactinomas ...
Vilar, Lucio; Abucham, Julio; Albuquerque, José Luciano; Araujo, Luiz Antônio; Azevedo, Monalisa F.; Boguszewski, Cesar Luiz; Casulari, Luiz AugustoProlactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction,...
A review of Cushing's disease treatment by the Department of Neuroendocrinology...
Machado, Márcio Carlos; Fragoso, Maria Candida Barisson Vilares; Moreira, Ayrton Custódio; Boguszewski, César Luiz; Vieira Neto, LeonardoThe treatment objectives for a patient with Cushing's disease (CD) are remission of hypercortisolism, adequate management of co-morbidities, restoration of the hypothalamic-pituitary-adrenal axis, preservation of fertility and pituitary function, and improvement of visual defects in cases of macroadenomas with suprasellar extension. Transsphenoidal pituitary surgery is the main treatment option for the majority...
Tratamento medicamentoso dos tumores hipofisários. Parte I : prolactinomas e ad...
Vilar, Lucio; Naves, Luciana Ansaneli; Freitas, Maria da Conceição; Oliveira Jr, Sebastião; Leite, Verônica; Canadas, VivianeO recente desenvolvimento de novas drogas, particularmente os análogos da somatotastina (SRIFa), representou um grande progresso na terapia dos tumores hipofisários. Os SRIFa mostram-se bastante eficazes na normalização dos níveis de GH e IGF-1 em acromegálicos e podem ser uma alternativa para a cirurgia transesfenoidal, mas seu uso como terapia primária da acromegalia fica limitado pelo pequeno efeito dessas d...
Aggressive prolactinoma in a child related to germline mutation in the ARYL hyd...
Naves, Luciana Ansaneli; Jaffrain-Rea, Marie-Lise; Vêncio, Sergio Alberto Cunha; Jacomini, Clausmir Zaneti; Casulari, Luiz Augusto; Daly, Adrian F.O objetivo deste estudo foi descrever o rastreamento familiar para mutações AIP em paciente portador de prolactinoma agressivo e resistente na infância. Um menino de 12 anos foi avaliado com queixa de cefaleia e hemianopsia bitemporal. Apresentava peso e altura adequados para a idade (percentil 50), estádio puberal Tanner G1 P1 e idade óssea de 10 anos. Prolactina 10.560 ng/mL (3-25), FSH e LH indetectáveis, IG...
The brazilian version of the Quality of Life Assessment of Growth Hormone Defic...
Oliveira Júnior, Antônio Ribeiro; Mol, Suélem Simão; Twiss, James; Alencar, Guilherme Asmar; Miranda, Paulo Augusto Carvalho; Naves, Luciana AnsaneliOBJETIVO: Este estudo relata o processo de adaptação da versão brasileira do questionário QoL-AGHDA (Quality of Life - Assessment of Growth Hormone Deficiency in Adults) para pacientes com deficiência do hormônio de crescimento (DGH). MATERIAIS E MÉTODOS: A tradução adotou a metodologia de duplo painel. O questionário foi testado por intermédio de entrevistas direcionadas com 16 pacientes com DGH. No estágio fi...
A review on the diagnosis and treatment of patients with clinically nonfunction...
Vieira Neto, Leonardo; Boguszewski, Cesar L.; Araújo, Luiz Antônio de; Bronstein, Marcello D.; Miranda, Paulo Augusto CarvalhoClinically nonfunctioning pituitary adenomas (NFPA) are the most common pituitary tumors after prolactinomas. The absence of clinical symptoms of hormonal hypersecretion can contribute to the late diagnosis of the disease. Thus, the majority of patients seek medical attention for signs and symptoms resulting from mass effect, such as neuro-ophthalmologic symptoms and hypopituitarism. Other presentations include...