6 documents found, page 1 of 1
Metabolomic Profiling in Lung Cancer: A Systematic Review
Madama, Daniela; Martins, Rosana; Pires, Ana S.; Botelho, Maria F.; Alves, Marco G.; Abrantes, Ana M.; Cordeiro, Carlos R.Lung cancer continues to be a significant burden worldwide and remains the leading cause of cancer-associated mortality. Two considerable challenges posed by this disease are the diagnosis of 61% of patients in advanced stages and the reduced five-year survival rate of around 4%. Noninvasively collected samples are gaining significant interest as new areas of knowledge are being sought and opened up. Metabolomi...
Single Low Dose of Cocaine-Structural Brain Injury Without Metabolic and Behavi...
Nicolucci, Camilla; Pais, Mariana Lapo; Santos, A. C.; Ribeiro, Fabiana M.; Encarnação, Pedro M. C. C.; Silva, Ana L. M.; Castro, I. F.Chronic cocaine use has been shown to lead to neurotoxicity in rodents and humans, being associated with high morbidity and mortality rates. However, recreational use, which may lead to addictive behavior, is often neglected. This occurs, in part, due to the belief that exposure to low doses of cocaine comes with no brain damage risk. Cocaine addicts have shown glucose metabolism changes related to dopamine bra...
Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonat...
Paulo, Siri; Laranjo, Mafalda; Abrantes, Ana M.; Casalta-Lopes, João; Santos, Kathleen; Gonçalves, Ana C.; Paula, Anabela Baptista; Marto, Carlos Miguel(1) Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the most often seen side effects in patients treated with nitrogen-containing bisphosphonates (BPs), a post-surgical non-healing wound condition. Since calcium phosphate (CP) compounds are able to adsorb zoledronate (ZOL) when used as a drug delivery vehicle, we aimed to verify if these ceramics might have a potential protective e...
Surface-PASylation of ferritin to form stealth nanovehicles enhances in vivo th...
Tesarova, Barbora; Dostalova, Simona; Smidova, Veronika; Goliasova, Zita; Skubalova, Zuzana; Michalkova, Hana; Hynek, David; Michalek, PetrSurface functionalisations substantially influence the performance of drug delivery vehicles by improving their biocompatibility, selectivity and circulation in bloodstream. Herein, we present the study of in vitro and in vivo behaviour of a highly potent cytostatic alkaloid ellipticine (Elli) encapsulated in internal cavity of ferritin (FRT)-based nanocarrier (hereinafter referred to as FRTElli). In addition, ...
Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhib...
Pires, Ana S.; Marques, Cláudia R.; Encarnação, João C.; Abrantes, Ana M.; Marques, Inês A.; Laranjo, Mafalda; Oliveira, Rui; Lopes, João E. CasaltaColorectal cancer (CRC) is continuously classified as one of the most incidental and mortal types of cancer worldwide. The positive outcomes of the conventional chemotherapy are frequently associated with high toxicity, which often leads to the suspension of the treatment. Growing evidences consider the use of pharmacological concentrations of ascorbic acid (AA), better known as vitamin C, in the treatment of c...
Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung car...
Rodrigues, Carlos F. D.; Serrano, Eurico; Patrício, Maria I.; Val, Mariana; Albuquerque, Patrícia; Fonseca, João; Gomes, Célia M. F.; Abrunhosa, AnteroCancer stem cells (CSCs) are a small population of resistant cells inhabiting the tumors. Although comprising only nearly 3% of the tumor mass, these cells were demonstrated to orchestrate tumorigenesis and differentiation, underlie tumors' heterogeneity and mediate therapy resistance and tumor relapse. Here we show that CSCs may be formed by dedifferentiation of terminally differentiated tumor cells under stre...