2 documents found, page 1 of 1
The use of the anticoagulant heparin and corticosteroid dexamethasone as promin...
Melo, Heloísa Antoniella Braz de; Faria, Sara Socorro; Nascimento, Gabriel Pasquarelli do; Santos, Igor de Oliveira; Kobinger, Gary P.COVID-19 is spreading worldwide at disturbing rates, overwhelming global healthcare. Mounting death cases due to disease complications highlight the necessity of describing efficient drug therapy strategies for severe patients. COVID-19 severity associates with hypercoagulation and exacerbated inflammation, both influenced by ACE2 downregulation and cytokine storm occurrence. In this review, we discuss the appl...
Hypercoagulopathy and adipose tissue exacerbated inflammation may explain highe...
Nascimento, Gabriel Pasquarelli do; Melo, Heloísa Antoniella Braz de; Faria, Sara Socorro; Santos, Igor de Oliveira; Kobinger, Gary P.COVID-19, caused by SARS-CoV-2, is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Several reports from around the world have identified obesity and severe obesity as one of the strongest risk factors for COVID-19 hospitalization and mechanical ventilation. Moreover, countries with greater obesity prevalence have a higher morbidity and mortality risk of developing serious ou...