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Polymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes ...
Nicchio, Ingra G. [UNESP]; Cirelli, Thamiris [UNESP]; Nepomuceno, Rafael [UNESP]; Hidalgo, Marco A.R. [UNESP]; Rossa, Carlos [UNESP]Made available in DSpace on 2022-04-29T08:36:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Background. Type 2 diabetes mellitus (T2DM) and periodontitis (P) commonly occur as comorbidities, but the commonalities in the genetic makeup of affected individuals is largely unknown. Since dyslipidemia is a frequent condition in these individuals, we investigate the association of genomic variations...
Validation in a Brazilian population of gene markers of periodontitis previousl...
Cirelli, Thamiris [UNESP]; Nepomuceno, Rafael [UNESP]; Orrico, Silvana R. P. [UNESP]; Rossa, Carlos [UNESP]; Cirelli, Joni A. [UNESP]; North, Kari E.Made available in DSpace on 2021-06-25T10:34:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01; Background: Bioinformatic tools and genome-wide association studies (GWAS) have led to comprehensive identification of single nucleotide polymorphisms (SNPs) associated with periodontitis in diverse populations. Here we aimed to detect and validate the association of seven SNPs as genetic markers of sus...
Association of type 2 diabetes mellitus and periodontal disease susceptibility ...
Cirelli, Thamiris [UNESP]; Nepomuceno, Rafael [UNESP]; Goveia, Jéssica Marina [UNESP]; Orrico, Silvana R. P. [UNESP]; Cirelli, Joni A. [UNESP]Made available in DSpace on 2021-06-25T10:48:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Objective: Genome-wide association studies (GWAS) and literature have identified polymorphisms in the KCNJ11, HNF1A, IRS1, TCF7L2, CDKAL1, CDKN2B, RPSAP52, GPR45 HHEX, IL18, and RUNX2 genes associated with type 2 diabetes mellitus (T2DM) and/or periodontitis (P) in diverse populations, and we sought to ...
Polymorphisms and haplotypes in the Interleukin 17 Alfa gene: potential effect ...
Rimachi Hidalgo, Marco A. [UNESP]; Cirelli, Thamiris [UNESP]; da Silva, Bárbara Roque [UNESP]; Nicchio, Ingra Gagno [UNESP]; Nepomuceno, Rafael [UNESP]Made available in DSpace on 2021-06-25T10:52:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Few studies evaluate interrelationships between periodontitis (P) and Type 2 Diabetes Mellitus (T2DM). The aim of this study is to investigate the genetic susceptibility t...
Genetic polymorphisms in the Interleukins IL1B, IL4, and IL6 are associated wit...
Cirelli, Thamiris [UNESP]; Nepomuceno, Rafael [UNESP]; Rios, Ana Cláudia S. [UNESP]; Orrico, Silvana R. P. [UNESP]; Cirelli, Joni A. [UNESP]Made available in DSpace on 2020-12-12T02:14:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Objective: To assess whether single nucleotide polymorphisms (SNPs) in the IL10, IL1A, IL1B, IL4, TNFA, IL6, OPG, RANK, and RANKL genes, “classically” related with periodontitis, could be associated with susceptibility to T2DM, and also with both diseases concomitantly. Background: There are common path...
Functional haplotype in the Interleukin8 (CXCL8) gene is associated with type 2...
Silva, Bárbara Roque da [UNESP]; Cirelli, Thamiris [UNESP]; Nepomuceno, Rafael [UNESP]; Theodoro, Letícia Helena [UNESP]; Orrico, Silvana R.P. [UNESP]Made available in DSpace on 2020-12-12T02:21:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-11-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Background and aim: Type 2 Diabetes Mellitus (T2DM) and Periodontitis (P) are prevalent multifactorial disorders worldwide, sharing a bidirectional relationship influenced...
Systemic expression of genes related to inflammation and lipid metabolism in pa...
Nepomuceno, Rafael [UNESP]; Vallerini, Bruna de F. [UNESP]; da Silva, Romerito L. [UNESP]; Corbi, Sâmia C.T. [UNESP]; Bastos, Alliny de S. [UNESP]Made available in DSpace on 2019-10-06T16:41:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Inflammatory diseases, as periodontal disease (PD), has been associated with disturbance of lipid and glycemic metabolisms, as demonstrated by the increasing of PD patients with type 2 diabetes mellitus (T2D) and/or dyslipidemia comorbiditie...
Association between interleukin-8 levels and chronic periodontal disease
Finoti, Livia S [UNESP]; Nepomuceno, Rafael [UNESP]; Pigossi, Suzane C [UNESP]; Corbi, Sâmia Ct [UNESP]; Secolin, RodrigoMade available in DSpace on 2018-12-11T17:12:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-06-01; Background: Current publications present contradictory findings regarding interleukin-8 (IL-8) levels in patients with chronic periodontitis (CP). This systematic review compile evidences of the IL8 mRNA and protein levels in gingival tissue, saliva, and gingival crevicular fluid (GCF) investigated in p...
Dyslipidemia rather than Type 2 Diabetes Mellitus or Chronic Periodontitis Affe...
Nepomuceno, Rafael [UNESP]; Villela, Bárbara Scoralick [UNESP]; Corbi, Sâmia Cruz Tfaile [UNESP]; Bastos, Alliny De Souza [UNESP]Made available in DSpace on 2018-12-11T17:14:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01; A high percentage of type 2 diabetes mellitus (T2D) patients are also affected by dyslipidemia and chronic periodontitis (CP), but no studies have determined the gene expression in patients that are simultaneously affected by all three diseases. We investigated the systemic expression of immune-related ...
Absolute quantification of Aggregatibacter actinomycetemcomitans in patients ca...
Cirelli, Thamiris [UNESP]; Finoti, Livia S. [UNESP]; Corbi, Sâmia C.T. [UNESP]; Anovazzi, Giovana [UNESP]; Nepomuceno, Rafael [UNESP]Made available in DSpace on 2018-12-11T16:50:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-10-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); This study aimed to evaluate the association between haplotypes in the interleukin 8 (IL8) and IL4 genes previously associated to chronic periodontitis (CP) and the levels of Aggregatibacter actinomycetemcomitans (A.a.) in subgingival sites ...