Made available in DSpace on 2022-04-29T08:41:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-04-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Background: Cancer is currently a major public health problem worldwide, with a marked increase of about 70% in the number of expected diagnosed cases over the next two decades. The amount of tobacco and alcohol consumed is calculated based ...