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Alves Lopes, António; Vieira, Ana Isabel; Azevedo, Vitor Hugo; Guimarães, Isabel; Neto, R


Low bone turnover is associated with plain X-ray vascular calcification in pred...

Neto, R; Pereira, L; Magalhães, J; Quelhas-Santos, J; Frazão, JM

Background Vascular calcification (VC) is a common finding in chronic kidney disease (CKD) patients and predicts subsequent cardiovascular morbidity and mortality in this population. Vascular calcification is linked to disordered mineral metabolism and has been associated with bone histomorphometry changes in CKD. However, data on predialysis patients is scarce. Methods A cross-sectional study was conducted on ...


Sclerostin and DKK1 circulating levels associate with low bone turnover in pati...

Neto, R; Pereira, L; Magalhães, J; Quelhas-Santos, J; Martins, S; Carvalho, C; Frazão, JM

Background: Disordered mineral and bone metabolism is a common complication of chronic kidney disease (CKD). Bone biopsy remains the gold standard tool for evaluating renal osteodystrophy (ROD), but it is an invasive procedure. Despite a growing interest in the ability of newer bone biomarkers to discriminate between different forms of ROD, data on pre-dialysis patients are scarce. Methods: A cross-sectional st...


Anemia and Iron Deficiency Diagnosis, Management and Treatment in Chronic Kidne...

Ferreira, A; Farinha, A; Macedo, A; Robalo Nunes, A; Lopes, J; Branco, P; Ponce, P; Neto, R

Background: Anemia is a common complication of Chronic Kidney Disease (CKD), in which iron deficiency’s (ID) role is frequently underrated. In CKD, anemia has been associated with higher morbidity and lower quality of life. Nonetheless, reported treatment rates of anemia in CKD are low and guidelines’ variability and/or absence for its management and treatment may be preventing patients from receiving optimal t...


Achieving K/DOQI Targets with Cinacalcet in Dialysis Patients with Secondary Hy...

Macário, F; Frazão, JM; Ferreira, A; Weigert, A; Mota, M; Machado, D; Birne, R; Neto, R; Baldaia Moreira, A; Soares, C; Ribeiro, S; Mendes, T; Alves, R

Secondary hyperparathyroidism is a common complication of chronic kidney disease. The elevated serum intact parathyroid hormone, phosphorus, calcium and calcium x phosphorus product have been independently associated with an increased relative risk of mortality. The standard therapy for secondary hyperparathyroidism, including active vitamin D analogues and phosphate binders, is often insufficient to allow pati...


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