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Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related ...

Costa, Allini Mafra da; Fregnani, José Humberto Tavares Guerreiro; Pastrez, Paula Roberta Aguiar; Mariano, Vânia Sammartino

The first publication that associated Human Papillomavirus (HPV) infection and esophageal cancer was published in 1982. However, data are still contradictory and require further investigation. The aim of this study was to identify high risk HPV DNA in esophageal tissue of patients with and without esophageal squamous cell carcinoma (ESCC) and correlate HPV presence with classical risk factors. METHODS: Invited ...


The relation of HPV infection and expression of p53 and p16 proteins in esophag...

Pastrez, Paula Roberta Aguiar; Mariano, Vânia Sammartino; Costa, Allini Mafra da; Silva, Estela Maria; Scapulatempo-Neto, Cristovam

GOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma. MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53 protein levels were assessed by immunohistochemistry (IHC). RESULTS: High-risk HPV (hr-HPV) wa...


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