12 documents found, page 1 of 2

Digital transformation in construction: Design and development of a house using...

Proteomic and Metabolic Analysis of Pinus halepensis Mill. Embryonal Masses Ind...

Understanding the physiological and molecular adjustments occurring during tree stress response is of great importance for forest management and breeding programs. Somatic embryogenesis has been used as a model system to analyze various processes occurring during embryo development, including stress response mechanisms. In addition, "priming" plants with heat stress during somatic embryogenesis seems to favor t...

The Impact of Moderate-to-High-Intensity Exercise Protocols on Glycated Hemoglo...

Type 2 diabetes mellitus (T2DM) is a growing global health issue that is closely linked to the epidemic of obesity. In addition to genetic factors, environmental and health-risk behaviours (i.e., high-carbohydrate diet and physical inactivity) contribute to a variety of pathophysiological disorders. Advanced exercise protocols, such as Moderate-to-intensity (MIT) and High Intensity Interval Training (HIIT), rev...

Establishment and characterization of human pluripotent stem cells-derived brai...

The establishment of robust human brain organoids to model cerebellar diseases is essential to study new therapeutic strategies for cerebellum-associated disorders. Machado-Joseph disease (MJD) is a cerebellar hereditary neurodegenerative disease, without therapeutic options able to prevent the disease progression. In the present work, control and MJD induced-pluripotent stem cells were used to establish human ...

Regeneration of Pinus halepensis (Mill.) through Organogenesis from Apical Shoo...

Organogenesis and somatic embryogenesis have been widely applied as the two main regeneration pathways in plant tissue cultures. However, recalcitrance is still the main restriction in the clonal propagation of many woody species, especially in conifers. They undergo a “phase change” that leads to significant loss of vegetative propagation capacity, reducing the aptitude of tissues and organs to be regenerated ...

Expansion of a specific plasmodium falciparum PfMDR1 Haplotype in southeast Asi...

Artemisinin-based combination therapies (ACTs) have been vital in reducing malaria mortality rates since the 2000s. Their efficacy, however, is threatened by the emergence and spread of artemisinin resistance in Southeast Asia. The Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) transporter plays a central role in parasite resistance to ACT partner drugs through gene copy number variations (CNV) a...

Caso dermatológico

Decorrente da melhoria dos padrões de saúde e nutrição, o escorbuto é atualmente menos prevalente, pelo que, nos dias de hoje, é um distúrbio pouco reconhecido na prática médica. Os sinais dermatológicos podem ser a única manifestação e são frequentemente confundidos com outras patologias. O diagnóstico precoce é fundamental já que, quando atempadamente abordado, o seu tratamento é simples e eficaz. Reportamos ...

Caso dermatológico

Decorrente da melhoria dos padrões de saúde e nutrição, o escorbuto é atualmente menos prevalente, pelo que, nos dias de hoje, é um distúrbio pouco reconhecido na prática médica. Os sinais dermatológicos podem ser a única manifestação e são frequentemente confundidos com outras patologias. O diagnóstico precoce é fundamental já que, quando atempadamente abordado, o seu tratamento é simples e eficaz. Reportamos ...

CUTANEOUS LUPUS ERYTHEMATOSUS - CLINICALPATHOLOGICAL CORRELATION OF LUPUS-SPECI...

Background: Lupus Erythematosus (LE) represents a multiorganic, autoimmune disease that affects mainly women of child-bearing age. The skin is the second most frequently affected organ, after the joints, and may precede the clinical onset of systemic symptoms.Objectives: To present the clinical findings which evoke the possibility of LE-specific skin lesions and the histopathological findings that may co-substa...

DERMOSCOPY - SELECTED CASES OF UNDEREXPLORED APPLICATIONS AND REVIEW OF THE LIT...

Introduction: The scope of dermoscopy extends beyond the evaluation of pigmented lesions, particularly in the assessment of vascular, infectious and inflammatory lesions as well as in the scalp and nail diseases. We aim to show dermoscopic features that may be useful in the diagnosis and follow-up of non-melanocytic lesions.Material and Methods: We selected 19 patients in whom dermoscopy was used for diagnosis ...