24 documents found, page 1 of 3
Interplay between western diet and mammary cancer: data from a chemically-induc...
Silva, J; Azevedo, T; Aires, I; Peixoto, F; Neuparth, MJ; Faustino-Rocha, AI; Duarte, JA; Oliveira, PABackground/Aim: This study aimed to investigate the influence of Western diet on mammary cancer in Wistar female rats, focusing on systemic responses and tumor development. Materials and Methods: Twenty-eight Wistar female rats were acclimatized and divided into four experimental groups (n=7 each): Western diet (WD), Western diet with N-methyl-N- nitrosourea (MNU) administration (WD+MNU), standard diet (CTR), a...
Long-term exposure to supraphysiological levels of testosterone impacts rat sub...
Valente-Santos, J; Vitorino, R; Sousa-Mendes, C; Oliveira, Paula; Colaço, B; Faustino-Rocha, Ana; Neuparth, MJ; Leite-Moreira, A; Duarte, JAThe salivary glands play a central role in the secretion of saliva, whose composition and volume affect oral and overall health. A lesser-explored dimension encompasses the possible changes in salivary gland proteomes in response to fluctuations in sex hormone levels. This study aimed to examine the effects of chronic exposure to testosterone on salivary gland remodeling, particularly focusing on proteomic adap...
Appraising animal models of prostate cancer for translational research: future ...
Nascimento-Gonçalves, E; Seixas, F; Gil da Costa, R; Pires, MJ; Neuparth, MJ; Moreira-Gonçalves, D; Fardilha, M; Faustino-Rocha, Ana I; Colaço, BThe growing incidence of prostate cancer has prompted a great investment in basic biology and translational studies to develop new therapies. Multiple animal models have been established to study etiological factors, cancer-preventive strategies and the molecular determinants of aggressiveness and metastases. The rat model of prostate cancer induced by chemical carcinogen N-methyl-N-nitrosourea (MNU) and testos...
The role of natural compounds in rat mammary cancer: the beneficial effects of ...
Azevedo, Tiago; Silva, J; Faustino-Rocha, Ana I; Valada, A; Anjos, L; Moura, T; Ferreira, T; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, FBreast cancer is the most diagnosed cancer among women, and a leading cause of death worldwide. Santolina chamaecyparissus L. is a plant with multiple health benefits, includ- ing anticancer and anti-diabetic properties. This study aimed to assess the chemopreven- tive effects of S. chamaecyparissus aqueous ex- tract (SCE) in an animal model of mammary cancer. A total of 28 four-week-old female Wistar rats were...
Lifelong exercise training promotes the remodelling of the immune system and pr...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJ; Moreira-Gonçalves, DThis work aimed to understand how lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of PCa. Fifty-five male Wistar rats were divided into four groups: control sedentary, control exercised, induced PCa sedentary and induced PCa exercised. Exercised animals were trained in a treadmill for 53 weeks. Pca induction consisted on the sequential administratio...
Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus...
Medeiros, C; Silva, AR; Ferreira, T; Barros, L; Neuparth, MJ; Peixoto, F; Bastos, MMSM; Medeiros, R; Gil da Costa, RM; Pires, MJ; Faustino-Rocha, Ana Infections with certain types of papillomavirus, such as the human papillomavirus 16 (HPV16), are associated with the development of preneoplastic lesions and cancers of the anogenital, and head and neck regions. Cytinus hypocistis (L.) L. extracts are composed of substances presenting antiproliferative, antioxidant, anti-inflammatory and antibacterial properties, which might be promising as new therapeutic comp...
Moderate intensity treadmill exercise influences the immune system and prostate...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Fonseca, C; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJMaterial & Methods: Fifty-five male Wistar rats were divided into: control sedentary (SED+CONT; n=10), control exercised (EX+CONT; n=10), induced sedentary (SED+PCa; n=15), and induced exercised (EX+PCa; n=20). Exercised animals were trained in a treadmill, for 53 weeks. PCa induction consisted of flutamide and N-methyl-N-nitrosourea administration, followed by testosterone propionate implants. At sacrifice, pr...
Chemopreventive effects of Santolina chamaecyparissus in a rat model of chemica...
Azevedo, T; Faustino-Rocha, Ana I; Silva, J; Valada, A; Anjos, L; Moura, T; Ferreira, R; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, F; Seixas, FChemopreventive effects of Santolina chamaecyparissus in a rat model of chemically- induced mammary cancer
Immune system and prostate signalome in a rat model of prostate cancer: influen...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Fonseca, C; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJImmune system and prostate signalome in a rat model of prostate cancer: influence of lifelong exercise training
Unveiling the role of moderate exercise training in immune system and prostate ...
Nascimento-Gonçalves, E; Seixas, F; Palmeira, C; Martins, G; Fonseca, C; Duarte, JA; Faustino-Rocha, Ana I; Colaço, B; Pires, MJ; Neuparth, MJBackground: Prostate cancer (PCa) is among the most prevalent cancers worldwide. This work aimed to under- stand the effects of exercise training in a rat model of PCa chemically and hormonally-induced. Material and Methods: Fifty-five male Wistar rats were divided into: control sedentary (SED+CONT; n=10), control exercised (EX+CONT; n=10), induced seden- tary (SED+PCa; n = 15) and induced exercised (EX+PCa; n=...