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Acetylcholinesterase Choline-Based Ionic Liquid Inhibitors: In Vitro and in Sil...
Siopa, Filipa; Frade, Raquel F. M.; Diniz, Ana; Andrade, Joana M.; Nicolai, Marisa; Meirinhos, Ana; Lucas, Susana D.; Marcelo, FilipaCOMPETE Programme: SAICTPAC/0019/2015 IF/00780/2015 Project no. 022161; Monocationic and dicationic cholinium ionic liquids (ILs) were synthesized and evaluated as acetylcholinesterase (AChE) inhibitors with in vitro and in silico models, and their cytotoxicity was assessed using human cell lines from skin (CRL-1502) and colon cancer (CaCo-2). The ILs with a longer alkyl chain were stronger AChE inhibitors, the...
Date: 2018
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Origin: Repositório Institucional da UNL