35 documents found, page 1 of 4

Identification and Characterization of Myeloid-Derived Suppressor Cells (MDSC) ...

Introduction: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate under pathological conditions, such as cancer, and suppress immune responses through various mechanisms. Distinguishing MDSC populations remains challenging due to their shared surface markers with neutrophils and monocytes, complicating accurate identification and quantification. This...

Exploring the fate of phlorotannins from Laminaria digitata across the gastroin...

Phlorotannins are phenolic compounds exclusive from brown macroalgae endowed with promising bioactive properties. However, considering that diet is their main route of entrance to our system, gastrointestinal digestion might affect such bioactive properties. Here, phlorotannin extracts obtained from Laminaria digitata were submitted to simulated gastrointestinal digestion to evaluate its impact on their antioxi...

Lavandula viridis L´Hér. Essential oil inhibits the inflammatory response in ma...

Lavandula viridis L´Hér. Essential Oil Inhibits the Inflammatory Response in Ma...

Lavandula viridis L´Hér. is an endemic Iberian species with a high essential oil yield and a pleasant lemon scent. Despite these interesting features, this species remains unrecognized and poorly explored by the food and pharmaceutical industries. Nevertheless, it has been valued in traditional medicine being used against flu, circulatory problems and to relieve headaches. Since these disorders trigger inflamma...

Competências para a gestão de um repositório institucional: o caso do repositór...

É num cenário de abertura crescente da ciência, mais amplo e complexo, que se impõem novas competências aos gestores de repositórios. Este estudo visa identificar os papéis e as competências necessárias à gestão e organização de um repositório institucional. Trata-se de um estudo qualitativo com observação participante, suportado pela revisão da literatura, que permitiu refletir sobre o papel dos gestores de re...

A visão dos gestores de repositórios. O caso da Universidade de Coimbra

O Movimento do Acesso Aberto é uma importante referência na transformação do processo de comunicar a ciência. Um dos aspetos mais relevantes que resultou do Movimento do Acesso Aberto foi o aparecimento dos repositórios digitais das instituições universitárias, com o intuito de preservar e maximizar o impacto da investigação realizada, possibilitando novos modelos de investigação e contribuindo para a afirmação...

O Papel do Poder Marítimo e Naval Português vi

Ao longo do século XVIII, o mar assume-se como palco de competição e conflito à escala global, onde velhas tensões entre as principais potências europeias se projetam e confrontam. A manutenção da soberania e interesses nacionais, bem como a ligação e presença nos territórios ultramarinos, passam a depender da capacidade de edificar e manter os meios necessários para exercer o poder no mar. A investigação reali...

Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens...

Experimental evidence highlights nuclear factor (erythroid-derived 2)-like 2 (Nrf2) as a molecular target in Alzheimer's disease (AD). The well-known effect of electrophilic cysteine-reactive skin allergens on Nrf2-activation led to the hypothesis that these compounds could have a therapeutic role in AD. This was further supported by the neuroprotective activity of the skin allergen dimethyl fumarate (DMF), dem...

Behaviour of charged spinning massless particles

We revisit the classical theory of a relativistic massless charged point particle with spin and interacting with an external electromagnetic field. In particular, we give a proper definition of its kinetic energy and its total energy, the latter being conserved when the external field is stationary. We also write the conservation laws for the linear and angular momenta. Finally, we find that the particle’s velo...

A topological-like model for gravity in 4D space-time

In this paper we consider a model for gravity in four-dimensional space-time originally proposed by Chamseddine, which may be derived by dimensional reduction and truncation from a five-dimensional Chern–Simons theory. Its topological origin makes it an interesting candidate for an easier quantization, e.g., in the loop quantization framework. The present paper is dedicated to a classical analysis of the model’...