3 documents found, page 1 of 1
Characterization of the striatal extracellular matrix in a mouse model of Parki...
Freitas, A; Aroso, M; Barros, A; Fernández, M; Conde-Sousa, E; Leite, M; Carvalho, ED; Ribeiro, CC; Ferreira, R; Pêgo, AP; Vitorino, R; Gomez-Lazaro, MParkinson’s disease’s etiology is unknown, although evidence suggests the involvement of oxidative modifications of intracellular components in disease pathobiology. Despite the known involvement of the extracellular matrix in physiology and disease, the influence of oxidative stress on the matrix has been neglected. The chemical modifications that might accumulate in matrix components due to their long half-li...
Exercise training impacts cardiac mitochondrial proteome remodeling in murine u...
Ferreira, R; Neuparth, M; Nogueira-Ferreira, R; Magalhães, S; Aroso, M; Bovolini, J; Santos, L; Oliveira, P; Vitorino, R; Moreira-Gonçalves, DCardiac dysfunction secondary to cancer may exert a negative impact in patients’ tolerance to therapeutics, quality of life, and survival. The aim of this study was to evaluate the potential therapeutic effect of exercise training on the heart in the setting of cancer, after diagnosis. Thus, the molecular pathways harbored in heart mitochondria from a murine model of chemically-induced urothelial carcinoma subm...
Biological implications of differential expression of mitochondrial-shaping pro...
Rocha, S; Freitas, A; Guimarães, SC; Vitorino, R; Aroso, M; Gomez-Lazaro, MIt has long been accepted that mitochondrial function and morphology is affected in Parkinson’s disease, and that mitochondrial function can be directly related to its morphology. So far, mitochondrial morphological alterations studies, in the context of this neurodegenerative disease, have been performed through microscopic methodologies. The goal of the present work is to address if the modifications in the m...