14 documents found, page 1 of 2
Assessing Moisture Content Using Infrared Thermography: Preliminary Results
Dafico, L; Eva Barreira; Neves, D; Vicente, R; Almeida, MSFMoisture is one of the main causes of defects in buildings, compromising not only the durability of materials and components, but also the indoor comfort and health conditions of users. Infrared thermography (IRT) is a technique that has great potential for mapping humidity in buildings but quantitative criteria that correlate differences in surface temperatures with the moisture content are lacking. This paper...
Metformin reverses infertility in a mouse model of endometriosis: unveiling dis...
Neto, AC; Botelho, M; Rodrigues, AR; Lamas, S; Araújo, B; Guimarães, JT; Gouveia, AM; Almeida, H; Neves, D" Research question: Does metformin reverse endometriosis-associated infertility? Design: Endometriosis was induced by transplanting uterus fragments from B6CBAF1 mice into recipients of the same strain. The mice were divided into groups: endometriosis (End, n = 24), sham-operated (Sham, n = 12), endometriosis with metformin (0.5mg/ml) orally administered for 3 months (EndMet, n = 21) and sham-operated metformi...
GLP-1 Increases Circulating Leptin Levels in Truncal Vagotomized Rats
Morais, T; Pereira, SS; Andrade, S; Neves, D; Guimaraes, M; Nora, M; Carreira, MC; Casanueva, FF; Monteiro, MPGLP-1 is a gastro-intestinal hormone acting within the gut/brain axis for energy balance regulation. We aimed to evaluate the role of the vagus nerve in whole-body energy homeostasis and in mediating GLP-1 effects. For this, rats submitted to truncal vagotomy and sham-operated controls underwent a comprehensive evaluation, including eating behavior, body weight, percentage of white (WAT) and brown adipose tissu...
The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models
Neto, AC; Santos Pereira, M; Abreu Mendes, P; Neves, D; Almeida, Henrique; Francisco Cruz; Charrua A.<jats:p>The different definitions of chronic pelvic/visceral pain used by international societies have changed over the years. These differences have a great impact on the way researchers study chronic pelvic/visceral pain. Recently, the role of systemic changes, including the role of the central nervous system, in the perpetuation and chronification of pelvic/visceral pain has gained weight. Consequently, rese...
Metformin Prevents Endothelial Dysfunction in Endometriosis through Downregulat...
Martins, AF; Neto, AC; Rodrigues, AR; Oliveira, SM; Sousa Mendes, C; Leite-Moreira, AF; Gouveia, Alexandra; Almeida, Henrique; Neves, D
Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PG...
Pereira, AS; Gouveia, AM; Tomada, N; Rodrigues, AR; Neves, DCardiovascular disease risk factors (CVDRF), especially diabetes mellitus (DM), disrupt oxidative stress response. This condition underlies endothelial dysfunction, early manifested in men as erectile dysfunction. The current study is aimed at elucidating the impact of CVDRF in the oxidation responsive AMPK/SIRT1-PGC-1-SIRT3 pathway and related miRNAs in the human corpus cavernosum. Human penile tissue fragment...
Energy restriction, exercise and atorvastatin treatment improve endothelial dys...
Rocha, B; Rodrigues, AR; Tomada, I; Martins, MJ; Guimarães, J; Gouveia, AM; Almeida, H; Neves, DBackground: Endothelial dysfunction underlies cardiovascular disease that frequently affects aged individuals. Characterized by local decrease in nitric oxide, it results from down-regulation of endothelial nitric oxide synthase (eNOS) expression/activity. Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet ...
Natural mineral-rich water ingestion by ovariectomized fructose-fed Sprague-Daw...
Das, JK; Severo, M; Pereira, CD; Patrício, E; Magalhães, J; Monteiro, R; Neves, D; Martins, MJObjective: Prevention or induction of metabolic disorders and obesity depend on estrogen signaling and/or exogenous factors, such as mineral content in diet. The protective effects of a Portuguese natural mineral-rich water against the induction of metabolic syndrome in fructose-fed male Sprague-Dawley rats have been reported. The present study was designed to assess the impact of this mineral-rich water on fru...
Estimation of the collective ionizing dose in the Portuguese population for the...
Costa, F; Teles, P; Nogueira, A; Barreto, A; Santos, A I; Carvalho, A; Martins, B; Oliveira, C; Gaspar, C; Barros, C; Neves, D; Costa, D; Rodrigues, EIn 2009-2010 a Portuguese consortium was created to implement the methodologies proposed by the Dose Datamed II (DDM2) project, aiming to collect data from diagnostic X-ray and nuclear medicine (NM) procedures, in order to determine the most frequently prescribed exams and the associated ionizing radiation doses for the Portuguese population. The current study is the continuation of this work, although it focus...
Role of physical exercise on hepatic insulin, glucocorticoid and inflammatory s...
Passos, E; Pereira, CD; Gonçalves, IO; Rocha-Rodrigues, S; Silva, N; Guimarães, JT; Neves, D; Ascensão, A; Magalhães, J; Martins, MJAims Pro-inflammatory mediators, glucocorticoids and transforming growth factor (TGF)-β are implicated in the pathogenesis of non-alcoholic steatohepatitis (NASH)-related insulin resistance. As physical activity is beneficial against NASH, we analyzed the voluntary physical activity (VPA) and endurance training (ET) (preventive and therapeutic strategies) effects on hepatic insulin, pro-inflammatory and glucoco...