29 documents found, page 1 of 3
Metformin treatment decreases placenta fibrosis in a murine model of surgically...
Moreira, Anaisa; Rodrigues, Adriana; Gouveia, A.M.; Almeida, H.; Neto, A.C.; Neves, D.
Characterization of α-MSH browning effect in the distinct fat depots from obese...
Salazar, M.J.; Rodrigues, A.R.; Neves, D.; Almeida, Henrique; Magalhães, J.; Gouveia, Alexandra
The melanocortins against obesity-induced adipose tissue dysfunction: role in i...
Rodrigues, A.R.; Salazar, M.J.; Neves, D.; Almeida, Henrique; Gouveia, Alexandra
Energy restriction, exercise and atorvastatin treatment improve endothelial dys...
Rocha, B.; Rodrigues, A. R.; Tomada, I.; Martins, M. J.; Guimarães, J. T.; Gouveia, A. M.; Almeida, H.; Neves, D.Background: Endothelial dysfunction underlies cardiovascular disease that frequently affects aged individuals. Characterized by local decrease in nitric oxide, it results from down-regulation of endothelial nitric oxide synthase (eNOS) expression/activity. Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet ...
Intervention of diabetes mellitus and metabolic risk factors in AMPK-PGC1-SIRT3...
Santos Pereira, A.; Rodrigues, A.R.; Rocha. B; Tomada, N.; Gouveia, Alexandra; Neves, D.
Assessing left ventricular dysfunction by the use of three distinct molecular i...
Reis, J.; Cunha, L.; Costa, Pedro; Neves, D.; Oliveira, T.; Ferrer-Antunes, A.; João, M. Faria; Metelo, Luís FranciscoLeft ventricular dysfunction might be assessed using distinct molecular imaging modalities. The most relevant are first pass radionuclide ventriculography (FPRV), multigated radionuclide angiography (MUGA) and gated blood-pool SPECT (GBPS) and are very often used for monitoring chemotherapy-related cardiomyopathy. This work aims to correlate these three molecular imaging techniques.
Estimation of the collective ionizing dose in the Portuguese population for the...
Costa, F.; Teles, P.; Nogueira, A.; Barreto, A.; Santos, A.I.; Carvalho, A.; Martins, B.; Oliveira, C.; Gaspar, C.; Barros, C.; Neves, D.; Costa, D.Objectives: In 2009-2010 a Portuguese consortium was created to implement the methodologies proposed by the Dose Datamed II (DDM2) project, aiming to collect data from diagnostic X-ray and nuclear medicine (NM) procedures, in order to determine the most frequently prescribed exams and the associated ionizing radiation doses for the Portuguese population. The current study is the continuation of this work, altho...
Effects of aging and cardiovascular disease risk factors on the expression of s...
Freitas, M.; Rodrigues, A.R.; Tomada, N.; Fonseca, J.; Magalhaes, AL; Gouveia, Alexandra; Neves, D.Introduction. Sirtuin (SIRT) 1 was recently identified in human corpus cavernosum (CC). We hypothesized that other sirtuins could also be expressed in the CC. Expression of these enzymes in tissues is affected by aging, the main independent risk factor for erectile dysfunction besides other cardiovascular disease risk factors (CVDRF), such as diabetes or obesity. Aim. The aim of this study was to characterize t...
Experimental activities in science teaching of children with special educationa...
Neves, D.; Ferreira, Maria Eduarda; Reis, Carlos; Loureiro, M.The study developed fits science education area, designated in Portuguese Preschool Education by Environment Knowledge. In particular, we explored the theme of physical states of water. We build learning pathways by using practical-experimental activities as methodology. The problem of this research study is to understand whether the practices and experimental activities in science contribute to learning of chi...
Effects of high-fat diet, energy restriction, exercise and atorvastatin treatme...
Fernandes, D.; Tomada, Inês; Gouveia, Alexandra; Santos, A. Navarrete; Simm, A.; Almeida, H.; Neves, D.