16 documents found, page 1 of 2
Dissection of the microRNA transcriptomes of CD4+ T cell subsets in autoimmune ...
Cunha, Carolina; Romero, Paula Vargas; Inácio, Daniel; Pais, Ana Teresa; Pelicano, Catarina; Costa, Marina; Mensurado, Sofia; Gonçalves-Sousa, NatachaMicroRNAs (miRNAs) are key regulators of CD4+ T cell differentiation, but how they contribute to the course of an autoimmune disease in vivo remains poorly studied. Given the known roles in autoimmunity of pro-inflammatory T helper 1 (Th)1 and Th17 cells, and anti-inflammatory Foxp3+ regulatory cells, we established a triple reporter mouse for Ifng, Il17 and Foxp3, and subjected it to experimental autoimmune en...
Avaliação dos padrões de seguimento nutricional em crianças, unidade especial d...
Cardoso, Francisco Manuel; Díaz, Niurka Taureaux; Neves, Daniel; Baptista, GoreteA avaliação periódica do crescimento infantil, permite a detecção dos desvios e tomada de decisões. A presença da criança num serviço de saúde é uma oportunidade para reavaliação e educação para saúde. É importante conhecer as técnicas, valorizar o registo e periodicidade da recolha. Vários estudos demonstram que a desnutrição infantil é uma ameaça para as nações, porque as crianças que sofrem da desnutrição cr...
Perfil epidemiológico de casos de abandono do tratamento da tuberculose num hos...
Clemente, Koko Lomani Ngand; Diaz, Niurka T.; Neves, Daniel; Baptista, GoretePesquisa orientada sobre avaliação do perfil epidemiológico dos casos, abandono do tratamento de tuberculose, no Hospital Boa entrada Cáda, de 2019 a 2022. Problema da saúde pública, na persistencia da fonte da infecção, aumento da taxa de recidiva, mortalidade, facilitar o desenvolvimento de capas de bacilos resistentes.
A long noncoding RNA promotes parasite differentiation in African trypanosomes
Guegan, Fabien Marc; Rajan, K. Shanmugha; Bento, Fabio; Neves, Daniel; Sequeira, Mariana; Gumińska, Natalia; Mroczek, Seweryn; Dziembowski, AndrzejThe parasite Trypanosoma brucei causes African sleeping sickness that is fatal to patients if untreated. Parasite differentiation from a replicative slender form into a quiescent stumpy form promotes host survival and parasite transmission. Long noncoding RNAs (lncRNAs) are known to regulate cell differentiation in other eukaryotes. To determine whether lncRNAs are also involved in parasite differentiation, we ...
Influence of bicycle crossing location at urban multi-lane roundabouts on poten...
Fernandes, Paulo; Neves, Daniel; Coelho, Margarida C.Conventional bicycles, e-bikes and e-scooters have become extensively used with the associated growing traffic safety concerns. Understanding the main differences in injury risks perceived by these two-wheeler (2Ws) riders in collisions with motor vehicles at intersections is essential. This paper intended to create an analysis methodology based on PC-Crash accident reconstruction to examine the potential kinem...
"A vontade de ser, move montanhas!": Entrevista
Neves, Daniel; Ganhão, Jéssica; Diogo, Elisete; Anile, LorenaNesta entrevista, a Maria de Fátima Matos (MFM) percorre minuciosamente o seu percurso profissional. De uma forma espontânea, inteligente e cativante, relata‐nos histórias de uma carreira marcada pela humanização, pela resiliência e força de vontade, e, acima de tudo, pelo amor à profissão de Assistente Social.Numa conversa informal, será possível, ao ler esta entrevista, testemunhar que as nossas raízes e a no...
γδ-T cells promote IFN-γ–dependent Plasmodium pathogenesis upon liver-stage inf...
Ribot, Julie; Neres, Rita; Zuzarte-Luis, Vanessa; Gomes, Anita Q.; Mancio-Silva, Liliana; Mensurado, Sofia; Neves, Daniel; Monteiro Dos Santos, MiguelCerebral malaria (CM) is a major cause of death due to Plasmodium infection. Both parasite and host factors contribute to the onset of CM, but the precise cellular and molecular mechanisms that contribute to its pathogenesis remain poorly characterized. Unlike conventional αβ-T cells, previous studies on murine γδ-T cells failed to identify a nonredundant role for this T cell subset in experimental cerebral mal...
Trypanosoma brucei parasites occupy and functionally adapt to the adipose tissu...
Trindade, Sandra; Rijo-Ferreira, Filipa; Carvalho, Tânia; Neves, Daniel; Guegan, Fabien Marc; Aresta-Branco, Francisco; Bento, Fabio; Young, Simon A.Trypanosoma brucei is an extracellular parasite that causes sleeping sickness. In mammalian hosts, trypanosomes are thought to exist in two major niches: early in infection, they populate the blood; later, they breach the blood-brain barrier. Working with a well-established mouse model, we discovered that adipose tissue constitutes a third major reservoir for T. brucei. Parasites from adipose tissue, here terme...
How stuttering and speech therapy changed my life?
Neves, Daniel; Largo, BritoSpeech therapy intervention for stuttering situations can be constituted as a set of narrative processes that transform the vision patients have of themselves and of their lives related with others and with the social context. This acts directly on promoting their quality of life allowing them to live their preferred lives. This type of intervention promotes empowerment of the patient.
Evaluation of performance of industrial-scale dual fluidized bed gasifiers usin...
Larsson, Anton; Seemann, Martin; Neves, Daniel; Thunman, HenrikA general approach to evaluating the performance of industrial-scale dual fluidized bed (DFB) gasifiers was developed in this work. The approach is intended to simplify comprehensive evaluation of DFB gasifiers and to highlight important parameters, some of which are often missed or omitted in the literature. By applying this procedure, experimental results can be generalized, which is verified in this work using t...