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Anti-inflammatory and metabolic effects of lentil phenolic compounds

Geraldo, Rafaela; Gouveia, Alexandra; Neves, Delminda; Freitas, Victor; Pinto, Elisabete; Vasconcelos, Marta W.


Effects of dietary polyphenols on vasculogenic erectile dysfunction: a systemat...

Geraldo, Rafaela; Castro, Catarina; Pinto, Elisabete; Vasconcelos, Marta W.; Neves, Delminda

Erectile dysfunction (ED) is a medical condition characterized by the inability to achieve or maintain a satisfactory erection, primarily treated with oral phosphodiesterase type 5 inhibitors. Treatment effectiveness is diminished in severe vasculogenic ED, particularly in patients with diabetes mellitus, highlighting the need for exploring alternative/complementary interventions. Among them, dietary phenolic c...


Oat and lentil-based muffins as a functional food: enhance glycaemia control, a...

Geraldo, Rafaela; Machado, Manuela; Silva, Sara; Pinho, Simão; Gouveia, Alexandra; Neves, Delminda; Pinto, Elisabete; Pintado, Manuela

The increased interest in functional foods has driven research into health-promoting properties. This study evaluated muffins made with 100 % oatmeal (OM) or a 50:50 lentil/oatmeal flour mix (LM) using the INFOGEST in vitro model. Analysis included starch composition, glycaemic response, cytotoxicity, and immunomodulatory effects in Caco-2 cells under basal and stimulated conditions. Digestion revealed limited ...


Exploring the health benefits of lentil phenolics: antioxidant and immunomodula...

Geraldo, Rafaela A. F.; Machado, Manuela; Silva, Sara; Costa, Eduardo M.; Pinto, Elisabete; Pintado, Manuela; Neves, Delminda; Vasconcelos, Marta W.

Introduction: Lentils are rich in essential nutrients such as protein, fibre, and flavonoids, with a low glycemic index that helps avoid glycemia peaks. Epidemiological data suggest potential benefits against cardiovascular diseases and diabetes. Objectives: Identify the lentil variety with the highest phenolic and flavonoid content, antioxidant capacity, and anti-diabetic effects while evaluating its cytotoxic...


Nutritional value and environmental footprint of muffins made with green-lentil...

Geraldo, Rafaela; Santos, Carla S.; Styles, David; Sousa, Sérgio; Pinto, Elisabete; Neves, Delminda; Vasconcelos, Marta W.

The growing interest in environmentally friendly and protein-rich food choices has prompted the food industry to explore alternative protein sources. Lentils have garnered attention due to their versatile culinary applications and the range of health benefits associated with their nutritional composition. Furthermore, lentils offer an environmentally sustainable solution as they require fewer resources than ani...


Characterization of TGF-β expression and signaling profile in the adipose tissu...

Sousa-Pinto, Bernardo; Gonçalves, Laura; Rodrigues, Adriana R.; Tomada, Inês; Almeida, Henrique; Neves, Delminda; Gouveia, Alexandra M.

Transforming growth factor beta (TGF-β) plays an important role in the pathogenesis of obesity, influencing the release of inflammation mediators and promoting remodeling and collagen deposition in the adipose tissue (AT). In this context, this work aims to elucidate whether TGF-β and Smad-dependent or Smad-independent signaling pathways contribute to regional differentiation of AT in high-fat diet (HFD) and en...


Expression of TGF-beta in different adipose tissue depots is singularly regulat...

Sousa-Pinto, Bernardo; Gonçalves, Laura; Rodrigues, Adriana; Tomada, Inês; Almeida, Henrique; Neves, Delminda; Gouveia, Alexandra


Dieta híper -lipídica e restrição energética associam-se a um aumento da expres...

Sousa - Pinto, Bernardo; Gonçalves, Laura; Rodrigues, Adriana; Salazar, Maria João; Tomada, Inês; Almeida, Henrique; Neves, Delminda; Gouveia, Alexandra


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