5 documents found, page 1 of 1
Antimicrobial peptides: Identification of two beta-defensins in a teleost fish,...
Barroso, C; Carvalho, P; Gonçalves, JFM; Rodrigues, P; Neves, JVBeta-defensins consist in a group of cysteine-rich antimicrobial peptides (AMPs), widely found throughout vertebrate species, including teleost fish, with antimicrobial and immunomodulatory activities. However, although the European sea bass (Dicentrarchus labrax) is one of the most commercially important farmed fish species in the Mediterranean area, the characterization of its beta-defensins and its potential...
The Era of Antimicrobial Peptides: Use of Hepcidins to Prevent or Treat Bacteri...
Barroso, C; Carvalho, P; Nunes, M; Gonçalves, JFM; Rodrigues, P; Neves, JVThe current treatments applied in aquaculture to limit disease dissemination are mostly based on the use of antibiotics, either as prophylactic or therapeutic agents, with vaccines being available for a limited number of fish species and pathogens. Antimicrobial peptides are considered as promising novel substances to be used in aquaculture, due to their antimicrobial and immunomodulatory activities. Hepcidin, ...
The diverse piscidin repertoire of the european sea bass (Dicentrarchus labrax)...
Barroso, C; Carvalho, P; Carvalho, C; Santarém, N; Gonçalves, JFM; Rodrigues, P; Neves, JVFish rely on their innate immune responses to cope with the challenging aquatic environment, with antimicrobial peptides (AMPs) being one of the first line of defenses. Piscidins are a group of fish specific AMPs isolated in several species. However, in the European sea bass (Dicentrarchus labrax), the piscidin family remains poorly understood. We identified six different piscidins in sea bass, performed an in-...
Hepcidin-dependent regulation of erythropoiesis during anemia in a teleost fish...
Neves, JV; Caldas, C; Ramos, M; Rodrigues, PNAnemia is a common disorder, characterized by abnormally low levels of red blood cells or hemoglobin. The mechanisms of anemia development and response have been thoroughly studied in mammals, but little is known in other vertebrates, particularly teleost fish. In this study, different degrees of anemia were induced in healthy European sea bass specimens (Dicentrarchus labrax) and at pre-determined time points ...
Transcription factor NRF2 protects mice against dietary iron-induced liver inju...
Silva-Gomes, S; Santos, AG; Caldas, C; Silva, CM; Neves, JV; Lopes, J; Carneiro, F; Rodrigues, PN; Duarte, TLBACKGROUND & AIMS: The liver, being the major site of iron storage, is particularly exposed to the toxic effects of iron. Transcription factor NRF2 is critical for protecting the liver against disease by activating the transcription of genes encoding detoxification/antioxidant enzymes. We aimed to determine if the NRF2 pathway plays a significant role in the protection against hepatic iron overload.METHODS: Wil...