44 documents found, page 1 of 5

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Inter rater disagreements in applying the montreal classification for Crohn's d...

Ukashi, Offir; Amiot, Aurelien; Laharie, David; Menchén, Luis; Gutiérrez, Ana; Fernandes, Samuel; Pessarelli, Tommaso; Correia, Fábio

Background: The Montreal classification has been widely used in Crohn's disease since 2005 to categorize patients by the age of onset (A), disease location (L), behavior (B), and upper gastrointestinal tract and perianal involvement. With evolving management paradigms in Crohn's disease, we aimed to assess the performance of gastroenterologists in applying the Montreal classification. Methods: An online survey ...


Clinical significance of histologic healing in IBD: evidence from randomized co...

Estevinho, Maria Manuela; Roseira, Joana; Teixeira, Pedro Vilela; Dignass, Axel; Magro, Fernando

Histologic mucosal healing (HMH) has emerged as a crucial target in managing inflammatory bowel disease, complementing the established goal of endoscopic mucosal healing. This review evaluates the significance of HMH in both Crohn's disease (CD) and ulcerative colitis (UC). In UC, strong evidence shows that HMH correlates with improved long-term outcomes, including reduced hospitalization rates, and decreased n...


Thiopurines have no impact on outcomes of Crohn's disease patients beyond 12 mo...

Sousa, Paula; Patita, Marta; Arroja, Bruno; Lago, Paula; Rosa, Isadora; Sousa, Helena Tavares; Ministro, Paula; Mocanu, Irina; Vieira, Ana

The emergence of new treatments the inflammatory bowel diseases (IBD) raised questions regarding the role of older agents, namely thiopurines. Aims: To clarify the benefits of combination treatment with thiopurines on Crohn's disease (CD) patients in the maintenance phase of infliximab. Methods: In this analysis of the 2 -year prospective multicentric DIRECT study, patients were assessed in terms of clinical ac...


Clinical Trials in Portugal: Past and Future. Position Paper from the Colleges ...

Borges-Carneiro, Filipa; Torre Souto, Miguel; Silva, Isabel; Leão Moreira, Paula; Ferraz de Oliveira, Paula; Lopes, Diogo José; Figueira, Luís

N/a.; N/a.

Date: 2024   |   Origin: Acta Médica Portuguesa

Clinical Trials in Portugal: Past and Future. Position Paper from the Colleges ...

Borges-Carneiro, Filipa; Torre Souto, Miguel; Silva, Isabel; Leão Moreira, Paula; Ferraz de Oliveira, Paula; Lopes, Diogo José; Figueira, Luís


How to Evaluate Fibrosis in IBD?

Sousa, Helena Tavares; Magro, Fernando

In this review, we will describe the importance of fibrosis in inflammatory bowel disease (IBD) by discussing its distinct impact on Crohn's disease (CD) and ulcerative colitis (UC) through their translation to histopathology. We will address the existing knowledge on the correlation between inflammation and fibrosis and the still not fully explained inflammation-independent fibrogenesis. Finally, we will compi...


How many biomarker measurements are needed to predict prognosis in Crohn's dise...

Magro, Fernando; Estevinho, Maria Manuela; Catalano, Gaia; Patita, Marta; Arroja, Bruno; Lago, Paula; Rosa, Isadora; Sousa, Helena Tavares

BackgroundTimely stratification of Crohn's disease (CD) is essential for patients' management. The use of noninvasive accurate biomarkers is key to monitor treatment and to pursue mucosal healing, the ultimate treatment endpoint in CD. ObjectiveWe aimed to evaluate the performance of readily available biomarkers and develop risk matrices to predict CD progression. MethodsData from 289 CD patients receiving infl...


Thiopurines: Use them or lose them? International survey on current and future ...

Sousa, Paula; Ministro, Paula; Armuzzi, Alessandro; Dignass, Axel; Høivik, Marte Lie; Barreiro-de Acosta, Manuel; Vavricka, Stephan

Made available in DSpace on 2022-04-29T08:30:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Background and aims: The role of thiopurines in therapeutic algorithms of Crohn's disease (CD) and Ulcerative colitis (UC) is being questioned. This work aimed to investigate current practice and future perspectives of Inflammatory Bowel Disease (IBD) physicians regarding the efficacy, safety, and role ...

Date: 2022   |   Origin: Oasisbr

Transmural remission improves clinical outcomes up to 5 years in Crohn's disease

Fernandes, Samuel Raimundo; Serrazina, Juliana; Botto, Inês Ayala; Leal, Tiago; Guimarães, Andreia; Garcia, Joana Lemos; Rosa, Isadora; Prata, Rita

IntroductionEvidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long-term. MethodsMulticenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colonosco...


Transmural remission improves clinical outcomes up to 5 years in Crohn's disease

Fernandes, Samuel; Serrazina, Juliana; Botto, Inês Ayala; Leal, Tiago; Guimarães, Andreia; Garcia, Joana Lemos; Rosa, Isadora; Prata, Rita

© 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptation...


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