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Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of ...
Carneiro, Tatiana J.; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Neves, João R.; Carvalho, Ana L. M. Batista de; Marques, Maria Paula M.; Diniz, CarmenThe new palladium agent Pd2Spermine (Spm) has been reported to exhibit promising cytotoxic properties, while potentially circumventing the known disadvantages associated to cisplatin therapeutics, namely acquired resistance and high toxicity. This work presents a nuclear magnetic resonance (NMR) metabolomics study of brain extracts obtained from healthy mice, to assess the metabolic impacts of the new Pd2Spm co...
Date: 2022
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Origin: Estudo Geral - Universidade de Coimbra