8 documents found, page 1 of 1

Clotrimazole-loaded N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chito...

Lipid nanocarriers for anti-HIV therapeutics: a focus on physicochemical proper...

Since HIV was first identified, and in a relatively short period of time, AIDS has become one of the most devastating infectious diseases of the 21st century. Classical antiretroviral therapies were a major step forward in disease treatment options, significantly improving the survival rates of HIV-infected individuals. Even though these therapies have greatly improved HIV clinical outcomes, antiretrovirals (AR...

Electrospun fibers for vaginal administration of tenofovir disoproxil fumarate ...

Women are particularly vulnerable to sexual HIV-1 transmission. Oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine (TDF/FTC) is highly effective in avoiding new infections in men, but protection has only been shown to be moderate in women. Such differences have been associated, at least partially, to poor drug penetration of the lower female genital tract and the need for ...

TDF/FTC electrospun nanofibers for topical prevention of HIV transmission

Human immunodeficiency virus (HIV) is still a problem for global health so, there is a strong need to develop effective microbicides that can be used safely to protect from infection during sexual intercourse. This pre-exposure prophylaxis (PrEP) may be formulations containing oral or topical microbicides. Topical formulations have advantages as they are suitable for vaginal or rectal application and allow a hi...

Novel strategies for cancer treatment: drug delivery combining graphene quantum...

[Excerpt] Cancer remains a global health problem and according to the International Agency for Research on Cancer, the incidence of all cancer cases will raise from 12.7 million new cases in 2008 to 21.2 million by 20301 . Doxorubicin (DOX) is considered one of the main “first-line” anticancer drugs. However, besides being a wide-spectrum antitumor drug its clinical application is limited as it is often associa...

Control release of acyclovir nanocristals from electrospun nanofibers: comparis...

The objective of this study is to develop a novel system for cutaneous application of ACV that is capable of a controlled release of the drug overcoming the limitations of the conventional topical formulations.

Co-delivery of two anti-HIV drug nanocrystals from electrospun nanofibers

TRUVADA is the only medication approved by FDA for pre-exposure prophylaxis of the HIV infection. They are tablets with fixed dosages of two antiretroviral compounds for daily oral uptake: Tenofovir disoproxil fumarate (TDF) and Emtricitabine (EMT) that are reverse transcriptase inhibitors. Objectives:  Incorporate TDF and EMT drugs in polymeric nanofibers produced by electrospinning; chosen polymers were poly...

Release of acyclovir from polymeric nanofibers: comparing aqueous versus membra...

The objective of this study is to develop a novel system for acyclovir (ACV) controlled release after cutaneous application through the encapsulation of the drug into polymeric nanofibers of policaprolactone (PCL) produced by the electrospinning technique to overcome the limitations of the conventional topical formulations.