11 documents found, page 1 of 2
Rapid and long-lasting antidepressant-like effects of ketamine and their relati...
Viana, Glauce S. B.; Vale, Eduardo Mulato do; Araujo, A. R. A. de; Coelho, N. C.; Andrade, S. M.; Costa, R. O. da; Aquino, Pedro Everson Alexandre deKetamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting antidepressant effects, but how the drug shows its sustained effects is still a matter of controversy. The objectives were to evaluate the mechanisms for KET rapid (30 min) and long-lasting (15 and 30 days after) antidepressant effects in mice. A single dose of KET (2, 5, or 10 mg/kg, po) was administered to male Swiss mice ...
The treadmill exercise protects against dopaminergic neuron loss and brain oxid...
Costa, Roberta Oliveira da; Gadelha-Filho, Carlos Vinicius Jataí; Costa, Ayane Edwiges Moura da; Feitosa, Mariana Lima; Araújo, Dayane Pessoa deParkinson’s disease (PD), a progressive neurological pathology, presents motor and nonmotor impairments. The objectives were to support data on exercise benefits to PD. Male Wistar rats were distributed into sham-operated (SO) and 6-OHDA-lesioned, both groups without and with exercise. The animals were subjected to treadmill exercises (14 days), 24 h after the stereotaxic surgery and striatal 6-OHDA injection. ...
The anti-inflammatory effects of N-methyl-(2S,4R)- trans -4-hydroxy- l -proline...
Aquino, Pedro Everson Alexandre de; Magalhães, Talita Rocha; Nicolau, Lucas Antonio Duarte; Leal, Luzia Kalyne Almeida MoreiraBackground Sideroxylon obtusifolium (Roem. & Schult.) T.D. Penn., Sapotaceae family, is a medicinal species native to the Brazilian Northeastern region. The plant is popularly used as an anti-inflammatory and hypoglycemic. Purpose To evaluate the anti-inflammatory properties of the N-methyl-(2S,4R)-trans-4-hydroxy-l-proline (NMP) from S. obtusifolium leaves in models of inflammation and to clarify its action me...
Pentoxifylline neuroprotective effects are possibly related to its anti-inflamm...
Neves, Kelly Rose Tavares; Nobre Júnior, Hélio Vitoriano; Leal, Luzia Kalyne Almeida Moreira; Andrade, Geanne Matos de; Brito, Gerly Anne de CastroPentoxifylline (PTX) is a phosphodiesterase inhibitor with anti-TNF-alpha activity, associated with its anti-inflammatory action. Considering Parkinson’s disease (PD) as a neuroinflammatory disorder, the objectives were to evaluate PTX neuroprotective properties, in a model of PD. Male Wistar rats, divided into sham-operated (SO), untreated 6-OHDA, and 6-OHDA treated with PTX (10, 25, and 50 mg/kg) groups, rece...
Curcumin reversion of neurochemical and immunohistochemical alterations in brai...
Lucetti, Elaine Cristina Pereira; Lucetti, Daniel Luna; Ribeiro, Ana Elisa da Silva; Moura, Rafael Barbosa de; Sampaio, Thayga Maria AraújoStroke is one leading cause of mortality and morbidity worldwide where free radicals production and inflammation play important roles. Curcumin, a curcuminoid from Curcuma longa presents several biological properties and is a potent anti-inflammatory and antioxidant agent. The objectives were to study the neuroprotective effects of curcumin on ischemic pups from mothers treated with this drug (25, 50 or 100 mg/...
Neuroprotective effects of piperine, an alkaloid from the Piper genus, on the P...
Correia, Alyne Oliveira; Cruz, Abílio Augusto Pimentel; Aquino, Arôdo Tenório Ribeiro de; Diniz, Joanisson Rubens GomesPiperine (PIP), an alkaloid from the Piper genus plants, presents biological properties, including potent anti-inflammatory actions. Since neuroinflammation plays a key role in Parkinson's disease (PD), the objectives were to evaluate the neuroprotective activity of PIP in a model of PD. Male Wistar rats were divided as: sham-operated (SO), untreated 6-OHDA (lesioned in the right striatum) and 6-OHDA lesioned a...
Neuroprotective properties of the standardized extract from Camellia sinensis (...
Pinto, Natália Bitu Pinto,; Alexandre, Bruno da Silva Alexandre; Neves, Kelly Rose Tavares; Silva, Aline Holanda; Leal, Luzia Kalyne Almeida MoreiraCamellia sinensis (green tea) is largely consumed, mainly in Asia. It possesses several biological effects such as antioxidant and anti-inflammatory properties. The objectives were to investigate the neuroprotective actions of the standardized extract (CS), epicatechin (EC) and epigallocatechin gallate (EGCG), on a model of Parkinson’s disease. Male Wistar rats were divided into SO (sham-operated controls), unt...
Omega-3 fatty acids : possible ceuroprotective mechanisms in the model of globa...
Nobre, Maria Elizabeth Pereira; Correia, Alyne Oliveira; Mendonça, Francisco Nilson Maciel; Uchoa, Luiz Ricardo AraújoBackground. Omega-3 (3) administration was shown to protect against hypoxic-ischemic injury. The objectives were to study the neuroprotective effects of 3, in a model of global ischemia. Methods. Male Wistar rats were subjected to carotid occlusion (30 min), followed by reperfusion. The groups were SO, untreated ischemic and ischemic treated rats with 3 (5 and 10 mg/kg, 7 days). The SO and untreated ischemic an...
Valproic acid neuroprotection in the 6-OHDA model of Parkinson’s disease is pos...
Ximenes, José Christian Machado; Neves, Kelly Rose Tavares; Leal, Luzia Kalyne Almeida Moreira; Carmo, Marta Regina Santos doParkinson’s disease is a neurodegenerative disorder where the main hallmark is the dopaminergic neuronal loss. Besides motor symptoms, PDalso causes cognitive decline. Although current therapies focus on the restoration of dopamine levels in the striatum, prevention or disease-modifying therapies are urgently needed. Valproic acid (VA) is a wide spectrum antiepileptic drug, exerting many biochemical and physiol...
Avaliação dos efeitos da Pentoxilina em modelo experimental de doença de Parkin...
Neves, Kelly Rose TavaresPentoxifylline (PTX) is a methylxanthine derivative that produces pharmacological effects by mechanisms as phosphodiesterase inhibition, increase in cAMP and cGMP levels and antagonism of A2A adenosine receptors. The drug also shows anti- inflammatory properties, due to the inhibition of TNF-alpha synthesis. The present work studied, by behavioral, neurochemical, histological and immunohistochemical methods, th...