23 documents found, page 1 of 3
Supported ionic liquid materials for L-asparaginase immobilization
Nunes, J. C. F.; Almeida, M. R.; Santos-Ebinuma, V. C.; Neves, M. C.; Freire, M. G.; Tavares, A. P. M.L-asparaginase (ASNase) (L-asparagine amidohydrolase EC 3.5.1.1) has been widely used as a therapeutic agent in the treatment of acute lymphoblastic leukemia (ALL) and in the food industry for the removal of toxic acrylamide (formed in foods cooked at high temperatures). Accordingly, ASNase is also used in biosensors for leukemia diagnosis. To improve the performance of ASNase and overcome the limitations of fr...
Pristine carbon nanotubes for an efficient L-asparaginase immobilization
Cristóvão, R. O.; Almeida, M. R.; Barros, M. A.; Nunes, J. C. F.; Boaventura, R. A.R.; Loureiro, J. M.; Faria, J. L.; Neves, M. C.; Freire, M. G.The enzyme L-asparaginase (ASNase) presents effective antineoplastic properties for acute lymphoblastic leukemia treatment, besides their potential use in the food sector to decrease acrylamide formation. Considering their applications, the improvement of these enzyme properties by efficient immobilization techniques is in high demand. Carbon nanotubes are promising enzyme immobilization supports since these ma...
Supported ionic liquids as efficient strategies to reduce environmental contami...
Francisco, R.; Neves, M. C.; Pereira, M. M.; Sousa, A. C. A.; Freire, M. G.Cytostatic drugs are one of the most used therapeutic options to treat cancer. Considering that cancer prevalence is increasing at a fast rate, the consumption of these drugs is expected to increase in the future. Upon administration, cytostatics are mainly excreted trough urine. This urinary excretion is responsible for the contamination of sewage, wastewater treatment plants (WWTPs) effluents, and ultimately ...
Supported Ionic Liquids as New Strategies to Reduce Toxicity of Cyclophosphamid...
Francisco, R.; Monteiro, B.; Venâncio, C.; Santos, M.; Silva, F. A. e; Neves, M. C.; Sousa, A.; Freire, M. G.Cancer prevalence increased rapidly over the last decades, with over 18 million new cancer cases in 2018. Consequently, the consumption of anti-cancer drugs such as cytostatics also increased. Given the expected escalation in cancer cases, and as a consequence in the consumption of cytostatics, it is expected that the levels of these highly toxic compounds in the urban water cycle will rise. Therefore, it is ne...
Development of innovative materials for antibiotics removal
Saraiva, A.; Neves, M. C.; Pastorinho, M. R.; Sousa, A. C. A.; Freire, M. G.Currently, about 100,000 tons of antibiotics are consumed each year worldwide, and its excessive and indiscriminate use has been causing serious environmental and public health issues, including the increase in antimicrobial resistance (AMR). According to the World Health Organization, AMR is one of the most important public health problems in the XXI century. Therefore, it has become imperative to develop new ...
New strategies for the removal of cytostatics from urine
Francisco, R.; Santos, A. C. A.; Neves, M. C.; Sousa, A. C. A.; Freire, M. G.Cytostatics drugs such as Mycophenolate Mofetil (MMF), Mycophenolic acid (MPA) and Capecitabine (CAP) are used in the treatment of cancer and also to prevent organ rejection after hepatic, renal, and cardiac transplants. However, cytostatic drugs are highly toxic and thus their handling and disposal is a matter of great concern. Supported ionic liquids (SILs) are promising materials to remove target compounds f...
Biocompatible excipients to enhance the stability of avian immunoglobulin Y (Ig...
Almeida, C. A. S.; Silva, L. C. V.; Silva, M. C.; Neves, M. C.; Freire, M. G.Immunoglobulins, also termed antibodies, are glycoproteins produced by jawed vertebrates, providing them immunity against bacteria, viruses, and other foreign agents1. Within the known numerous immunoglobulins classes, avian immunoglobulin Y (IgY), that can be found in the serum of chickens and other egg laying animals and also in egg yolk, is a promising antibody2. In contrast to its mammalian analogous immuno...
Preparation of supported ionic liquids as alternative adsorbents for cytostatic...
e Silva, F. A.; Rocha, B.; Neves, M. C.; Sousa, A. C. A.; Freire, M. G.Cancer prevalence is increasing at fast pace, with 18.1 million new cancer cases occurring in 2018 [1]. Advances in the pharma industry, particularly regarding cancer treatment, will boost survivorship and life quality of cancer patients. Within this framework, the consumption of anti-cancer drugs such as cytostatics is gaining momentum [2]. However, as with other active pharmaceutical ingredients, the excretio...
New opportunities brought about by supported ionic liquids within the removal o...
Silva, F. A.; Rocha, B.; Santos, M. J.; Neves, M. C.; Sousa, A. C. A.; Freire, M. G.With the cancer incidence growing worldwide, advances to provide enhanced therapies were undertaken by the medical field. As the consumption of anticancer drugs, namely cytostatics, increased, their occurrence and fate in the aquatic environment became a matter of high concern. In order to provide an adequate route to remove cytostatics from aqueous samples, supported ionic liquids (SILs) are here proposed. Thi...
Recovery and Purification of (Bio)Pharmaceuticals Using (Nano)Materials
Tavares, A. P. M.; Neves, M. C.; Trindade, T.; Freire, M. G.Biopharmaceuticals main classes comprise recombinant proteins, antibodies, and nucleic-acid-derived products, while synthetic pharmaceuticals include a wide variety of organic compounds. The purification of (bio)pharmaceuticals, as part of downstream processing, is mainly carried out by chromatographic processes, which are responsible for the therapeutics high cost. Therefore, there is a crucial need on the dev...