5 documents found, page 1 of 1
An insight into the synthesis of cationic porphyrin-imidazole derivatives and t...
Moreira, Xavier; Santos, Patricia; Faustino, M. Amparo F.; Raposo, M. Manuela M.; Costa, Susana P. G.; Moura, Nuno M. M.; Gomes, Ana T. P. C.New porphyrin-imidazole derivatives were synthesised by Radziszewski reaction between 2-formyl-5,10,15,20-tetraphenylporphyrin 1 and several (hetem)aromatic 1,2-diones, which after cationization afforded promising monocationic photosensitizers 3a-d. Singlet oxygen studies have demonstrated that all the cationic porphyrin-imidazole conjugates 3a-d were capable to produce cytotoxic species. These photosensitizers...
Antimicrobial Photodynamic Therapy against Endodontic Enterococcus faecalis and...
Diogo, Patrícia; Fernandes, Chantal; Caramelo, Francisco; Mota, Marta; Miranda, Isabel M.; Faustino, M. A. F.; Neves, M. G. P. M. S.Endodontic biofilms eradication from the infected root canal system remains as the primary focus in endodontic field. In this study, it was assessed the efficacy of antimicrobial Photodynamic Therapy (aPDT) with the Zn(II)chlorin e6 methyl ester (Zn(II)e6Me) activated by red light against monospecies and mixed biofilms of Enterococcus faecalis and Candida albicans. The results were compared with the ones obtain...
Influence of external bacterial structures on the efficiency of photodynamic in...
Pereira, M. A.; Faustino, M. A. F.; Tomé, J. P. C.; Neves, M. G. P. M. S.; Tomé, A. C.; Cavaleiro, J. A. S.; Cunha, Â.; Almeida, A.The main targets of photodynamic inactivation (PDI) are the external bacterial structures, cytoplasmic membrane and cell wall. In this work it was evaluated how the external bacterial structures influence the PDI efficiency. To reach this objective 8 bacteria with distinct external structures were selected; 4 Gram-negative bacteria (Escherichia coli, with typical Gram-negative external structures; Aeromonas sal...
Porphyrins as Antimicrobial Photosensitizing Agents
Almeida, A.; Cunha, A.; Faustino, M. A. F.; Tomé, A. C.; Neves, M. G. P. M. S.The emergence of microbial resistance to many of the major classes of antimicrobial drugs is becoming an increasing problem in the clinic and environmental areas. As such, the discovery of drugs with novel modes of action will be vital to meet the threats created by the emergence of resistance. Photodynamic antimicrobial chemotherapy is receiving considerable attention for its potentialities as a new form of an...
New porphyrin amino acid conjugates: synthesis and photodynamic effect in human...
Serra, V. Vaz; Zamarrón, A.; Faustino, M. A. F.; Iglesias-de la Cruz, M. C.; Blázquez, A.; Rodrigues, J. M. M.; Neves, M. G. P. M. S.The efficacy of new porphyrin amino acid conjugates as photosensitizers for photodynamic therapy (PDT) were assayed in vitro on tumoral (HeLa) and on non tumoral (HaCaT) human cell lines. The conjugates stable in liposomes are able to penetrate efficiently in the cytoplasm of cultured cancer and normal cells. No dark cytotoxicity is observed at the same concentration used for PDT cell treatment and during long ...