5 documents found, page 1 of 1
Multiple Myeloma Treatment Guidelines by the Portuguese Group of Multiple Myeloma
João, Cristina; Bergantim, Rui; Santos, Joana; Afonso, Celina; Bernardo, Paulo; Coelho, Henrique; Costa, Carlos; Esteves, Graça; Freitas, José GuilhermeThe treatment of multiple myeloma has profoundly changed with the introduction of several innovative therapies. The optimization of therapeutic sequencing through the combined use of the various drugs developed in recent years and the attention given to the characteristics of patients have allowed the reduction of toxicities and increased survival and quality of life of patients with multiple myeloma. These tre...
Plasmocitoma Extramedular Intrapancreático a Mimetizar uma Neoplasia Pancreátic...
Garrido Santos, João; Barros, Daniela; Lourenço, João; Neves, Manuel; Matos, CelsoO Plasmocitoma extramedular é uma neoplasia rara de células plasmáticas que ocorrem fora da medula óssea. O trato respiratório superior é o local mais comum onde são encontrados, sendo o envolvimento pancreático raro. Não apresenta características imagiológicas específicas e o diagnóstico definitivo requer habitualmente biópsia. Se ocorrer de forma localizada apresenta boa resposta à radioterapia; se ocorrer em...
Practical Considerations for the Daratumumab Management in Portuguese Routine C...
Geraldes, Catarina; Neves, Manuel; Chacim, Sérgio; da Costa, Fernando LealThe recent therapeutic progress in multiple myeloma (MM) has led to the introduction of novel and highly potent drug classes. Daratumumab was the first CD38-targeting antibody showing to be effective and safe in MM patients as monotherapy and in combination regimens, which led to its rapid implementation in clinical practice. Considering that treatment discontinuation for drug-related adverse events can impact ...
Nugget formation and mechanical behaviour of friction stir welds of three dissi...
Neves, Manuel; Galvão, Ivan; Leal, Rui; Costa, José D.; Loureiro, AltinoThe aim of this research was to investigate the influence of the properties of the base materials and welding speed on the morphology and mechanical behavior of the friction stir welds of three dissimilar aluminum alloys in a T-joint configuration. The base materials were the AA2017-T4, AA5083-H111, and AA6082-T6 alloys in 3 mm-thick sheets. The AA6082-T6 alloy was the stringer, and the other alloys were locate...
Annular Elastolytic Giant Cell Granuloma Associated with Polycythemia Vera
Albino, Cátia; Machado e Costa, Carlos; Neves, Manuel; Soares-de-Almeida, Luis; Braz Nogueira, J.Introduction: The authors describe a case of annular elastolytic giant cell granuloma (AEGCG) associated with polycythaemia vera. Both diseases resolved with treatment with hydroxyurea.Case report: A 63-year-old man refers fatigue, nausea, right upper abdominal pain and marked weight loss for 4 months. During last month he presents multiple grouped erythematous skin papules and plaques in his back. He had a mod...