7 documents found, page 1 of 1
Exploring anti-quorum sensing and anti-virulence based strategies to fight Cand...
Graínha, Tânia Raquel Rodrigues; Jorge, Paula Alexandra Silva; Pérez-Pérez, Martín; Rodríguez, Gael Pérez; Pereira, Maria OlíviaThe complex virulence attributes of Candida albicans are an attractive target to exploit in the development of new antifungals and anti-virulence strategies to combat C. albicans infections. Particularly, quorum-sensing (QS) has been reported as critical for virulence regulation in C. albicans. This work presents two knowledge networks with up-to-date information about QS regulation and experimentally tested an...
Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights thro...
Pérez-Pérez, Martín; Jorge, Paula; Rodríguez, Gael Pérez; Pereira, Maria Olívia; Lourenço, AnáliaQuorum sensing plays a pivotal role in Pseudomonas aeruginosas virulence. This paper reviews experimental results on antimicrobial strategies based on quorum sensing inhibition and discusses current targets in the regulatory network that determines P. aeruginosa biofilm formation and virulence. A bioinformatics framework combining literature mining with information from biomedical ontologies and curated databas...
A network perspective on antimicrobial peptide combination therapies: the poten...
Jorge, Paula; Pérez-Pérez, Martín; Rodríguez, Gael Pérez; Pereira, Maria Olívia; Lourenço, AnáliaSupplementary data associated with this article can be found, in the online version, at doi:10.1016/j.ijantimicag.2017.02.012.; Antimicrobial combinations involving antimicrobial peptides (AMPs) attract considerable attention within current antimicrobial and anti-resistance research. The objective of this study was to review the available scientific literature on the effects of antimicrobial combinations involv...
Reconstruction of the network of experimentally validated AMP-drug combinations...
Jorge, Paula; Pérez-Pérez, Martín; Rodríguez, Gael Pérez; Fdez-Riverola, Florentino; Pereira, Maria Olívia; Lourenço, AnáliaThe combination of antimicrobial products is a promising biomedical strategy against the ever growing number of resistant strains emerging in healthcare and community settings. Agents with alternative modes of action, such as antimicrobial peptides (AMPs), and the efficacy of combined actions are being evaluated. Despite the availability of various antimicrobial data repositories, a wealth of information remain...
Insights into Pseudomonas aeruginosa quorum sensing therapeutics through text- ...
Jorge, Paula Alexandra Silva; Pérez-Pérez, Martín; Rodríguez, Gael Pérez; Pereira, Maria Olívia; Lourenço, Anália Maria GarciaThe unceasing emergence of antibiotic-resistant strains and resilient biofilm-related infections is pressing researchers to develop novel antimicrobial strategies. Quorum sensing (QS) is a key communication mechanism that holds promise as target to control clinical pathogens. QS allows bacteria to regulate gene expression, and thus many physiological activities, such as virulence, motility, and biofilm formatio...
Construction of antimicrobial peptide-drug combination networks from scientific...
Jorge, P.; Pérez-Pérez, Martín; Rodríguez, Gael Pérez; Fdez-Riverola, Florentino; Pereira, Maria Olívia; Lourenço, AnáliaConsiderable research efforts are being invested in the development of novel antimicrobial therapies effective against the growing number of multi-drug resistant (MDR) pathogens. Notably, the combination of different agents is increasingly explored as means to exploit and improve individual agent actions while minimising microorganism resistance. Although there are several databases on antimicrobial agents, sci...
BEW: Bioinformatics workbench for analysis of biofilms experimental data
Rodríguez, Gael Pérez; Glez-Peña, Daniel; Azevedo, N. F.; Pereira, Maria Olívia; Fdez-Riverola, Florentino; Lourenço, AnáliaBiofilms research has evolved considerably in the last decade and is now generating large volumes of heterogeneous data. MIABiE, the international initiative on Biofilms, is devising guidelines for data interchange, and some databases provide access to biofilms experiments. However, the field is lacking appropriate bioinformatics tools in support of increasing operational and analytical needs. This paper presen...