45 documents found, page 1 of 5
Arrays of graphene-quantum dots-supported DNA oligonucleotides as self-indicati...
Monteiro, Ana R.; Ramos, Catarina I. V.; Fateixa, Sara; Neves, Maria G. P. M. S.; Trindade, TitoThe functionalization of deoxyribonucleic acid (DNA) with nanomaterials is a promising strategy to optimize the loading and efficiency of drugs in targeted clinical therapies. Herein we report a novel approach to construct arrays comprising blue- (B) or aqua green- (AG) emitting ethylenediamine-modified graphene quantum dots (GQDs) and DNA oligonucleotides that are able to fold into different structures, namely...
Ratiometric nanothermometry via porphyrin inner filter effect applied to colloi...
Conceição, Pedro; Barata, Joana F. B.; Hernández-Rodríguez, Miguel A.; Lacerda, Paula S. S.; Neves, Maria G. P. M. S.; Carlos, Luís D.; Trindade, TitoThermal sensing at the nanoscale is an attracted research field with potential applications in disparate areas from micro/nanoelectronics to nanomedicine. One of the driving forces of the research in the area is the design and fabrication of ratiometric thermometers combining materials with distinct thermometric properties. In this work, we provide an example of the combination of 5,10,15,20-tetrakis(pentafluor...
Development of catalyst-free approach to synthesize novel spiro[indoline-3,1′-p...
Abdelmouna, Khalid; Laghchioua, Fatima; Almeida Paz, Filipe A.; Mendes, Ricardo F.; Moura, Nuno M. M.; Faustino, Maria A. F.; Cavaleiro, José A. S.Spiro compounds are a class of naturally occurring organic molecules with a wide broad of applications in several fields, mainly in medicinal chemistry. Spirooxindoles have been considered by the scientific community as scaffolds for applications under medicinal purposes, namely as anticancer, antiviral, or antimicrobial agents. Due to this fact, the synthesis of spirocompounds, namely spirooxindoles is a hot t...
Interfacial assembly of zinc(II) phthalocyanines on graphene oxide (GO): stable...
Monteiro, Ana R.; Ramos, Catarina I. V.; Lourenço, Leandro M. O.; Fateixa, Sara; Rodrigues, Joana catarina; Neves, Maria G. P. M. S.; Trindade, TitoHypothesis The aggregation of phthalocyanines (Pcs) enfeebles their suitability as G-quadruplex (G4) ligands over time. It is hypothesized that the interfacial assembly of Pcs on graphene oxide (GO) influences intermolecular interactions, thereby affecting their physicochemical properties and inducing stabilization of Pcs in solution. Hence, the stacking of Pcs on GO could be tuned to create nanosystems with th...
Can corrole dimers be good photosensitizers to kill bacteria?
Lacerda, Paula S. S.; Bartolomeu, Maria; Gomes, Ana T. P. C.; Duarte, Ana S.; Almeida, Adelaide; Faustino, Maria A. F.; Neves, Maria G. P. M. S.Corroles possess key photophysical and photochemical properties to be exploited as thera-peutic agents in antimicrobial photodynamic therapy (aPDT). Herein, we present for the first time the antimicrobial efficiency of three corrole dimers and of the corresponding precursor against the Gram(+) bacterium Staphylococcus aureus. Additionally, to explore future clinical applications, the cytotoxicity of the most pr...
Graphene Oxide and Graphene Quantum Dots as Delivery Systems of Cationic Porphy...
Menilli, Luca; Monteiro, Ana Rita; Lazzarotto, Silvia; Morais, Filipe M. P.; Gomes, Ana T. P. C.; Moura, Nuno M. M.; Fateixa, SaraThe development of new photodynamic therapy (PDT) agents designed for bladder cancer (BC) treatments is of utmost importance to prevent its recurrence and progression towards more invasive forms. Here, three different porphyrinic photosensitizers (PS) (TMPyP, Zn-TMPyP, and P1-C5) were non-covalently loaded onto graphene oxide (GO) or graphene quantum dots (GQDs) in a one-step process. The cytotoxic effects of t...
New triazine bridged triads based on BODIPY-porphyrin systems: extended absorpt...
Souza, Marcos C.; Santos, Carla I. M.; Mariz, Inês; Marques, Bruno S.; Machado, Luana A.; Pedrosa, Leandro F.; Cavaleiro, José A. S.Two novel triads connecting a BODIPY to ethylenediamine substituted porphyrins via triazine linker have been synthesized and characterized. One of the triads is a linear D-A structure with one BODIPY (D) and one porphyrin (A) bridged by the triazine linker and the other one is a branched A-D4 structure with the porphyrin core linked to four BODIPY units. The triads show extended absorption in the visible region...
Tetracationic porphyrin derivatives against human breast cancer
Gamelas, Sara R. D.; Moura, Nuno M. M.; Habraken, Yvette; Piette, Jacques; Neves, Maria G. P. M. S.; Faustino, Maria A. F.Photodynamic therapy (PDT) is an approved therapeutic approach and an alternative to conventional chemotherapy for the treatment of several types of cancer with the advantages of reducing the side effects and developing resistance mechanisms. Here, was evaluated the photosensitization capabilities of 5,10,15,20-tetrakis[4-(pyridinium-1-yl-methyl)phenyl]porphyrin (3), its N-confused isomer (4) and of the neutral...
Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Ce...
Gomes, Ana T. P. C.; Fernandes, Rosa; Ribeiro, Carlos F. M.; Tomé, João P. C.; Neves, Maria G. P. M. S.; Silva, Fernando de C. da; Ferreira, Vítor F.Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of al...
New nitroindazole-porphyrin conjugates: synthesis, characterization and antibac...
Eddahmi, Mohammed; Sousa, Vera; Moura, Nuno M. M.; Dias, Cristina J.; Bouissane, Latifa; Faustino, Maria A. F.; Cavaleiro, José A. S.The synthesis of new porphyrin-indazole hybrids by a Knoevenagel condensation of 2-formyl-5,10,15,20-tetraphenylporphyrin and N-methyl-nitroindazolylacetonitrile derivatives is reported. The target compounds were isolated in moderate to good yields (32-57%) and some of the isolated porphyrin-indazole conjugates showed good performance in the generation of singlet oxygen when irradiated with visible light. Their...