266 documents found, page 1 of 27
The effect of conditioned medium from human amniotic membrane-derived mesenchym...
Silva, C. S.; Casanova, Marta Alexandra Rodrigues; Ferreirinha, P.; da Silva Morais, A.; Osório, H.; Lima, A. C.; Fangueiro, J. F.; Cerqueira, M. T.Aims: The development and selection of T cells occur within the thymus. This organ involutes throughout life, compromising the generation of T cells and, consequently, the efficacy of the immune system. Mesenchymal stem cells (MSC) have beneficial effects on the immune system. Therefore, MSC have been applied in different pathologies related with thymic function. However, there is a lack of knowledge on the pot...
MicroVasculoid-chip: a 3D self-assembled human microcirculation-on-a-chip model...
Abreu, Catarina M.; Lima, Ana Cláudia Fernandes; Neves, N. M.; Kundu, Subhas C; Reis, R. L.; Caballero, DavidThe microvasculature within the tumor microenvironment is crucial for the invasion and dissemination of cancer cells throughout the body. Given its importance and dynamic behavior, several microfluidic models have been developed to study microvascular infiltration and its interaction with cancer cells. However, most of these models primarily focus on blood vessels and use microfluidic channels coated with endot...
The potential of the fibronectin inhibitor Arg-Gly-Asp-Ser in the development o...
Castro-Ribeiro, Maria L.; Castro, Vânia Isabel Baptista; Castro, Joana vieira de; Pires, R. A.; Reis, R. L.; Costa, Bruno M.; Ferreira, HelenaGlioblastoma (GBM) is the most lethal and common malignant primary brain tumor in adults. An important feature that supports GBM aggressiveness is the unique composition of its extracellular matrix (ECM). Particularly, fibronectin plays an important role in cancer cell adhesion, differentiation, proliferation, and chemoresistance. Thus, herein, a hydrogel with mechanical properties compatible with the brain and...
Diaphragmatic hernia repair porcine model to compare the performance of biodegr...
Scuglia, Marianna; Frazão, Laura P.; Miranda, Alice Augusta Macedo; Martins, Albino; Barbosa-Sequeira, Joana; Coimbra, Diana; Longatto, AdhemarBackground Patch repair of congenital diaphragmatic hernia (CDH) using Gore-Tex® is associated with infection, adhesions, hernia recurrence, long-term musculoskeletal sequels and poor tissue regeneration. To overcome these limitations, the performance of two novel biodegradable membranes was tested to repair CDH in a growing pig model. Methods Twelve male pigs were randomly assigned to 3 diferent groups of 4 an...
Microfluidic-derived docosahexaenoic acid liposomes for targeting glioblastoma ...
Mendanha, Daniel; Casanova, Marta Alexandra Rodrigues; Gimondi, Sara; Ferreira, Helena Susana Costa Machado; Neves, N. M.Glioblastoma (GBM) is the most common malignant primary brain tumor, characterized by limited treatment options and a poor prognosis. Its aggressiveness is attributed not only to the uncontrolled proliferation and invasion of tumor cells but also to the complex interplay between these cells and the surrounding microenvironment. Within the tumor microenvironment, an intricate network of immune cells, stromal cel...
Plant-derived bioactive compounds as key players in the modulation of immune-re...
Vieira, Sara F.; Reis, R. L.; Ferreira, Helena Susana Costa Machado; Neves, N. M.The immune system is a complex and fundamental network for organism protection. A minimal unbalance in the host defense system homeostasis can originate severe repercussions in human health. Fundamentally, immune-related diseases can arise from its compromise (immunodeficiency diseases), overactivation against itself (autoimmune diseases) or harmless substances (allergies), and failure of eliminating the harmfu...
A facile strategy for tuning the density of surface-grafted biomolecules formel...
Beeren, I. A. O.; dos Santos, G.; Dijkstra, P. J.; Mota, C.; Bauer, J.; Ferreira, H.; Reis, R. L.; Neves, N. M.; Camarero-Espinosa, S.; Baker, M. B.Melt extrusion-based additive manufacturing (ME-AM) is a promising technique to fabricate porous scaffolds for tissue engineering applications.However,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell fate. Grafting of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct; however, there are limited strategies a...
COX-2 inhibitor delivery system aiming intestinal inflammatory disorders
Oliveira, Ana Isabel; Rodrigues, Luísa Cidália Guimarães; Soares da Costa, Diana; Fernandes, E. M.; Reis, R. L.; Neves, N. M.; Leão, P.; Martins, AlbinoSelective COX-2 inhibitors such as etoricoxib (ETX) are potentially indicated for the treatment of intestinal inflammatory disorders. However, their systemic administration provokes some off-site secondary effects, decreasing the desirable local effectiveness. To circumvent such limitations, herein an ETX delivery system based on electrospun fibrous meshes (eFMs) was proposed. ETX at different concentrations (1...
Intracellular trafficking of size-tuned nanoparticles for drug delivery
Gimondi, Sara; Ferreira, Helena Susana Costa Machado; Reis, R. L.; Neves, N. M.Polymeric nanoparticles (NPs) are widely used as drug delivery systems in nanomedicine. Despite their widespread application, a comprehensive understanding of their intracellular trafficking remains elusive. In the present study, we focused on exploring the impact of a 20 nm difference in size on NP performance, including drug delivery capabilities and intracellular trafficking. For that, poly(ethylene glycol) ...
Synthesis and anti-inflammatory evaluation of a library of chiral derivatives o...
Vieira, Sara Filipa Fontoura; Araújo, Joana; Gonçalves, Virgínia M. F.; Fernandes, Carla; Pinto, Madalena; Ferreira, Helena Susana Costa MachadoIn recent decades, the relationship between drug chirality and biological activity has been assuming enormous importance in medicinal chemistry. Particularly, chiral derivatives of xanthones (CDXs) have interesting biological activities, including enantioselective anti-inflammatory activity. Herein, the synthesis of a library of CDXs is described, by coupling a carboxyxanthone (1) with both enantiomers of prote...