10 documents found, page 1 of 1
Functional recovery of injured cavernous nerves achieved through endogenous ner...
Casanova, Marta R.; Mota, Paulo; Vala, Helena; Nóbrega, Carmen; Morais, Alain da Silva; Silva, Catarina S.; Barros, Alexandre A.; Reis, Rui L.Radical prostatectomy is a highly successful treatment for prostate cancer, among the most prevalent manifestations of the illness. Damage of the cavernous nerve (CN) during prostatectomy is the main cause of postoperative erectile dysfunction (ED). In this study, the capability of a personalized bioactive fibrous membrane to regenerate injured CN was investigated. The fibrous membrane bioactivity is conferred ...
Combination therapy with CD147‐targeted nanoparticles carrying phenformin decre...
Pereira-Nunes, Andreia; Ferreira, Helena; Abreu, Sara; Guedes, Marta; Neves, Nuno M.; Baltazar, Fátima; Granja, Sara; Granja, SaraLung cancer is one of the most fatal cancers worldwide. Resistance to conventional therapies remains a hindrance to patient treatment. Therefore, the development of more effective anti-cancer therapeutic strategies is imperative. Solid tumors exhibit a hyperglycolytic phenotype, leading to enhanced lactate production; and, consequently, its extrusion to the tumor microenvironment. Previous data reveals that inh...
Sardine roe as a source of lipids to produce liposomes
Guedes, Marta; Costa-Pinto, Ana Rita; Gonçalves, Virgínia; Moreira-Silva, Joana; Tiritan, Maria; Reis, Rui L.; Ferreira, Helena; Neves, Nuno M.Sea-derived materials have promising applications in the medical, pharmaceutical, and biotechnological fields. Fish roe, for example, is a highly nutritional product, presenting diverse beneficial effects on human health. Therefore, this work explored extracts of sardine (Sardina pilchardus) roe, due to the well-known health benefits of this fish, to produce novel and promising delivery systems. After morpholog...
Biofunctional nanofibrous substrate for local TNF-capturing as a strategy to co...
Bacelo, Elisa; Alves da Silva, Marta; Cunha, Cristina; Faria, Susana; Carvalho, Agostinho; Reis, R. L.; Martins, Albino; Neves, Nuno M.Rheumatoid arthritis (RA) is an autoimmune disease that affects the synovial cavity of joints, and its pathogenesis is associated with an increased expression of pro-inflammatory cytokines, namely tumour necrosis factor-alpha (TNF-α). It has been clinically shown to have an adequate response to systemic administration of TNF-α inhibitors, although with many shortcomings. To overcome such limitations, the immobi...
Influence of PDLA nanoparticles size on drug release and interaction with cells
Cartaxo, Ana Luísa; Costa-Pinto, Ana R.; Martins, Albino; Faria, Susana; Gonçalves, Virgínia M. F.; Tiritan, Maria Elizabeth; Ferreira, HelenaPolymeric nanoparticles (NPs) are strong candidates for the development of systemic and targeted drug delivery applications. Their size is a determinant property since it defines the NP–cell interactions, drug loading capacity, and release kinetics. Herein, poly(D,L-lactic acid) (PDLA) NPs were produced by the nanoprecipitationmethod, in which the influence of type and concentration of surfactant as well as PDL...
Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling ...
Kyrmizi, Irene; Ferreira, Helena; Carvalho, Agostinho; Figueroa, Julio Alberto Landero; Zarmpas, Pavlos; Cunha, Cristina; Akoumianaki, ToniaLC3-associated phagocytosis (LAP) is a non-canonical autophagy pathway regulated by Rubicon, with an emerging role in immune homeostasis and antifungal host defence. Aspergillus cell wall melanin protects conidia (spores) from killing by phagocytes and promotes pathogenicity through blocking nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent activation of LAP. However, the signalling regulati...
Calcium sequestration by fungal melanin inhibits calcium–calmodulin signalling ...
Kyrmizi, Irene; Ferreira, Helena; Carvalho, Agostinho; Figueroa, Julio Alberto Landero; Zarmpas, Pavlos; Cunha, Cristina; Akoumianaki, ToniaLC3-associated phagocytosis (LAP) is a non-canonical autophagy pathway regulated by Rubicon, with an emerging role in immune homeostasis and antifungal host defence. Aspergillus cell wall melanin protects conidia (spores) from killing by phagocytes and promotes pathogenicity through blocking nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent activation of LAP. However, the signalling regulati...
Intrinsic Antibacterial Borosilicate Glasses for Bone Tissue Engineering Applic...
Fernandes, Joao S.; Martins, Margarida; Neves, Nuno M.; Fernandes, Maria H. V.; Reis, Rui L.; Pires, Ricardo A.Three novel borosilicate bioactive glasses (BBGs) were prepared and used to investigate their bioactive and antibacterial properties. The BBGs were prepared by melt-quenching using different glass modifiers, i.e. Mg2+, Ca2+, and Sr2+, and their amorphous nature was confirmed by X-ray diffraction. Scanning electron microscopy with energy dispersive X-ray spectroscopy allowed the visualization of apatite-like str...
Complete Specification of APIs and Protocols for the MAFTIA Middleware
Armstrong, J.; Cachin, C.; Correia, Miguel; Costa, A.; Miranda, Hugo; Neves, Nuno Ferreira; Neves, Nuno M.; Poritz, J. A.; Randell, B.; Lung, Lau CheukThis document describes the complete specification of the APIs and Protocols for the MAFTIA Middleware. The architecture of the middleware subsystem has been described in a previous document, where the several modules and services were introduced: Activity Services; Communication Services; Network Abstraction; Trusted and Untrusted Components. The purpose of the present document is to make concrete the function...
First Specification of APIs and Protocols for the MAFTIA Middleware
Armstrong, J.; Cachin, C.; Correia, Miguel; Costa, A.; Miranda, Hugo; Neves, Nuno Ferreira; Neves, Nuno M.; Poritz, J. A.; Randell, B.; Lung, Lau CheukThis document describes the first specification of the APIs and Protocols for the MAFTIA Middleware. The architecture of the middleware subsystem has been described in a previous document, where the several modules and services were introduced: Activity Services; Communication Services; Network Abstraction; Trusted and Untrusted Components. The purpose of the present document is to make concrete the functionali...