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Redox–oligomeric state of peroxiredoxin-2 and glyceraldehyde-3-phosphate dehydr...

Valentim-Coelho, C; Vaz, F; Antunes, M; Neves, S; Martins, IL; Osorio, H; Feliciano, A; Pinto, P; Bárbara, C; Penque, D

In this study, we examined the effect of six months of positive airway pressure (PAP) therapy on Obstructive Sleep Apnea (OSA) red blood cell (RBC) proteome by two dimensional difference gel electrophoresis (2D-DIGE)-based proteomics followed by Western blotting (WB) validation. The discovered dysregulated proteins/proteoforms are associated with cell death, H2 O2 catabolic/metabolic process, stress response, a...


Effects of hyperleptinemia in rat saliva composition, histology and ultrastruct...

Lamy, Elsa; Neves, S; Ferreira, J; Rodrigues, Lénia; da Costa, G; Cordeiro, C; Fialho, Luisa; Lima, Mónica; Costa, Ana R.; Antunes, Célia M.

OBJECTIVE: To study the effect of the satiety hormone, leptin, in saliva proteome and salivary gland histology and ultrastructure. DESIGN: Increases in blood leptin levels were induced through mini-pump infusion in male Wistar rats, during a period of 7 days. Saliva was collected before and at the end of the experimental period, for proteomic analysis, and major salivary glands were collected, at the end, for b...


Idiopathic Pulmonary Fibrosis in the Era of Antifibrotic Therapy: Searching for...

Robalo-Cordeiro, C; Campos, P; Carvalho, L; Borba, A; Clemente, S; Freitas, S; Furtado, S; Jesus, JM; Leal, C; Marques, A; Melo, N; Souto-Moura, C

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease that up to now has been associated with a poor prognosis. However, the results of the INPULSIS and ASCEND trials and the approval of nintedanib and pirfenidone have marked the beginning of a new era for IPF patients. Questions remain, however. Should these drugs be used earlier? What effect will they have on more severe disease? Will th...


IRIS: Um novo índice de avaliação do risco de suicídio

Alte da Veiga, F; Andrade, J; Garrido, P; Neves, S; Craveiro, A; Santos, JC; Braz-Saraiva, C; Madeira, N

Na introdução os autores procedem a uma revisão histórica e conceptual dos instrumentos psicométricos que têm como objectivo a avaliação do risco de suicídio em indivíduos que apenas verbalizam ideação suicida. Nas secções seguintes é apresentado todo o processo de desenvolvimento do IRIS (Índice de Risco de Suicídio) - um novo índice com o mesmo objectivo de avaliação mas construído utilizando metodologias que...



MÓDULO 4 - Cirurgia, Anestesiologia, Ortopedia, Neurocirurgia, Oftalmologia e ORL

Brito, C; Rodrigues, F; Oliveira, G; Lopes, MF; Brito, MJ; Ribeiro, P; Neves, S; Cunha, C; Horta, P; Seabra, J; Conceição, V; Paiva, C; Monteiro, M




Fetopatia pelo uso de inibidores da enzima de conversão da angiotensina

Neves, S; Santos, R; Gomes, C; Correia, AJ

Angiotensin Converting Enzyme Inhibitors (ACEI) are commonly used antihypertensive drugs, although contraindicated during pregnancy by fetopathy association such as renal dysgenesis, oligohydramnios, hipocalvaria, pulmonary hypoplasia, intrauterine growth restriction, and neonatal anuric renal failure. The authors present a clinical report of a child that developed neonatal anuric renal failure with peritoneal ...


Soft-tissue foreign body (cactus thorn)

Brito, J; Neves, S; Curvo-Semedo, L; Caseiro-Alves, F

A 52-year-old woman complained of pain, swelling and functional impairment on the second digit of the hand 6 weeks after she punctured the finger with a cactus thorn.


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