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Profiling microglia in a mouse model of Machado–Joseph disease
Campos, Ana Bela; Silva, Sara Duarte; Fernandes, Bruno; Neves, Sofia Pereira das; Marques, Fernanda; Castro, Andreia Teixeira; Carvalho, Andreia NevesMicroglia have been increasingly implicated in neurodegenerative diseases (NDs), and specific disease associated microglia (DAM) profiles have been defined for several of these NDs. Yet, the microglial profile in Machado–Joseph disease (MJD) remains unexplored. Here, we characterized the profile of microglia in the CMVMJD135 mouse model of MJD. This characterization was performed using primary microglial cultur...
Exploring the role of astrocytes in the pathophysiology of multiple sclerosis
Neves, Sofia Pereira dasThe presence of reactive astrocytes in multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system, has been described for a long time, however its contribution for disease pathophysiology is still not fully understood. Therefore, in this work we proposed to further explore the contribution of astrocytes in MS using different experimental approaches. We started by performing a temporal...