3 documents found, page 1 of 1
Design, Synthesis and Antifungal Activity of New Schiff Bases Bearing 2-Aminoth...
Luna,Isadora S.; Neves,Wendell W.; Lima-Neto,Reginaldo G. de; Albuquerque,Amanda P. B.; Pitta,Maíra G. R.; Rêgo,Moacyr J. B. M.; Neves,Rejane P.Seventeen Schiff bases bearing 2-aminothiophene derivatives were designed and synthesized using molecular simplification. The resulting compounds (4a-4q) were evaluated for their in vitro antifungal activity against dermatophytes. Prediction of their druglikeness and pharmacokinetic properties, establishment of their structure-activity relationships (SAR), and cytotoxic evaluation of the most active compounds w...
Improvement of Solubility and Antifungal Activity of a New Aminothiophene Deriv...
Eleamen,Giovanna R. A.; Costa,Silvana C. da; Lima-Neto,Reginaldo G.; Neves,Rejane P.; Rolim,Larissa A.; Rolim-Neto,Pedro J.; Moura,Ricardo O.This study aimed to prepare a complex of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and 6CN10, a poorly water soluble 2-aminothiophene derivative with antifungal properties, by freeze-drying technique. The complex was characterized by thermal analysis, infrared/Raman spectroscopy, X-ray diffraction and scanning electron microscopy. In addition, we used the data of the phase solubility study, 1H, and 2D NMR spectr...
Application of MALDI-TOF MS for requalification of a Candida clinical isolates ...
Lima-Neto,Reginaldo; Santos,Cledir; Lima,Nelson; Sampaio,Paula; Pais,Célia; Neves,Rejane P.Microbial culture collections underpin biotechnology applications and are important resources for clinical microbiology by supplying reference strains and/or performing microbial identifications as a service. Proteomic profiles by MALDI-TOF MS have been used for Candida spp. identification in clinical laboratories and demonstrated to be a fast and reliable technique for the routine identification of pathogenic ...