3 documents found, page 1 of 1
Behavioral, affective, and cognitive alterations induced by individual and comb...
Rabelo-da-Ponte, Francisco Diego; Gomes, Jessica Maria Pessoa; Torres, Nathércia Lima; Barbosa, João Ilo Coelho; Andrade, Geanne Matos deObjective: To evaluate whether exposing rats to individual or combined environmental stressors triggers endophenotypes related to mood and anxiety disorders, and whether this effect depends on the nature of the behavior (i.e., innate or learned). Methods: We conducted a three-phase experimental protocol. In phase I (baseline), animals subjected to mixed schedule of reinforcement were trained to press a lever wi...
Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression...
Macedo, Danielle; Chaves Filho, Adriano José Maia; Sousa, Caren Nádia Soares de; Quevedo, João; Barichello, Tatiana; Nobre Júnior, Hélio VitorianoObjectives The first drug repurposed for the treatment of depression was the tuberculostatic iproniazid. At present, drugs belonging to new classes of antidepressants still have antimicrobial effects. Dysbiosis of gut microbiota was implicated in the development or exacerbation of mental disorders, such as major depressive disorder (MDD). Based on the current interest in the gut-brain axis, the focus of this na...
IDO chronic immune activation and tryptophan metabolic pathway : a potential pa...
Chaves Filho, Adriano José Maia; Lima, Camila Nayane Carvalho; Vasconcelos, Silvânia Maria Mendes; Lucena, David Freitas de; Maes, MichaelObesity and depression are among the most pressing health problems in the contemporary world. Obesity and depression share a bidirectional relationship, whereby each condition increases the risk of the other. By in- ference, shared pathways may underpin the comorbidity between obesity and depression. Activation of cell- mediated immunity (CMI) is a key factor in the pathophysiology of depression. CMI cytokines,...