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An Unstable Trinucleotide-Repeat Region on Chromosome 13 Implicated in Spinocer...

Vincent, John B.; Neves-Pereira, Maria L.; Paterson, Andrew D.; Yamamoto, Etsuko; Parikh, Sagar V.; Macciardi, Fabio; Gurling, Hugh M. D.

Larger CAG/CTG trinucleotide-repeat tracts in individuals affected with schizophrenia (SCZ) and bipolar affective disorder (BPAD) in comparison with control individuals have previously been reported, implying a possible etiological role for trinucleotide repeats in these diseases. Two unstable CAG/CTG repeats, SEF2-1B and ERDA1, have recently been cloned, and studies indicate that the majority of individuals wi...

Date: 2000   |   Origin: Estudo Geral - Universidade de Coimbra
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