2 documents found, page 1 of 1
Ação da Phα1β, peptídeo purificado do veneno da aranha Phoneutria nigriventer, ...
Tonello, RaquelFundação de Amparo a Pesquisa no Estado do Rio Grande do Sul; Opioids are the most common drugs prescribed worldwide for alleviating moderate to severe pain. However, the use of opioids is associated with the development of tolerance to the analgesic effect and potential adverse effects, such as paradoxical hyperalgesia, withdrawal syndrome and constipation. An important target for morphine-induced analgesia is...
Avaliação do potencial efeito antidepressivo do 2-BFI, ligante imidazolínico I2...
Tonello, RaquelFundação de Amparo a Pesquisa no Estado do Rio Grande do Sul; Depression is a complex, chronic and disabling psychiatric disease that carries a high social cost. Among the various classes of antidepressants are the monoamine oxidase A (MAO-A) inhibitors that reduce monoamine metabolism. An important site of MAO-A regulation is the imidazoline-2 binding site (I2). In fact, it was recently shown that 2-imidazolin...