7 documents found, page 1 of 1
Cannabidiol: brief compilation over a versatile molecule
Paula, Caico Bruno Curcio Oliva de; Baldacci, Enzo Andrade; Cheng, Lucas Chen; Gozzi, Mateus Bulbow; Shibuya, Pedro TorquatoCannabis sativa has been applied for medicinal purposes for thousands of years. Cannabidiol is the main non-psychotropic compound in Cannabis sativa, and has its therapeutic effect extremely linked to the central nervous system, presenting pharmacological properties with great potential for the treatment of several pathologies. The aim is to identify and relate the therapeutic effects of cannabidiol in medicine...
Scientific and Technological Forecasting about Covid-19: analysis of pharmacolo...
Oliveira, Antonio Carlos Pereira de; Fontenele, Darllan Damasceno; Sousa, Gabrielle Costa; Pinho, Samara Sousa de; Silva, Katriane Carvalho daSARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a virus with a high spreading capacity that can cause severe pneumonia. As there is still no effective treatment recommended by the World Health Organization (WHO), the present study aimed to conduct a scientific and technological forecasting, highlighting possible treatments that may be effective in combating COVID-19. The collection of articles a...
Efeito esofagoprotetor de um biopolímero, a goma do cajueiro, na doença do refl...
Nicolau, Lucas Antonio DuarteGastroesophageal reflux disease (GERD) can be defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus. Alternative ways of treatment must be considered since the standard therapy fails in all phenotypes of GERD, expressly in the most prevalent form (Non-Erosive Reflux Disease, NERD). We aimed to assess the esophageal mucosal protection effect of the biopolyme...
Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus ...
Nicolau, Lucas Antonio Duarte; Carvalho, Nathalia S.; Pacífico, Dvison M.; Lucetti, Larisse T.; Aragão, Karoline Sabóia; Véras, Leiz M.C.Objective This study aimed to investigate the protective effect of epiisopiloturine hydrochloride (EPI), an imidazole alkaloid, on NAP-induced gastrointestinal damage in rats. Methods Initially, rats were pretreated with 0.5% carboxymethylcellulose (vehicle) or EPI (3, 10 and 30 mg/kg, p.o. or i.p., groups 3–5, respectively) twice daily, for 2 days. After 1 h, NAP (80 mg/kg, p.o.) was given. The control group r...
The anti-inflammatory effects of N-methyl-(2S,4R)- trans -4-hydroxy- l -proline...
Aquino, Pedro Everson Alexandre de; Magalhães, Talita Rocha; Nicolau, Lucas Antonio Duarte; Leal, Luzia Kalyne Almeida MoreiraBackground Sideroxylon obtusifolium (Roem. & Schult.) T.D. Penn., Sapotaceae family, is a medicinal species native to the Brazilian Northeastern region. The plant is popularly used as an anti-inflammatory and hypoglycemic. Purpose To evaluate the anti-inflammatory properties of the N-methyl-(2S,4R)-trans-4-hydroxy-l-proline (NMP) from S. obtusifolium leaves in models of inflammation and to clarify its action me...
Role of the NO/KATP pathway in the protective effect of a sulfated-polysacchari...
Damasceno, Samara Rodrigues Bonfim; Rodrigues, Jocélia C.; Silva, Renan O.; Nicolau, Lucas Antonio Duarte; Chaves, Luciano S.; Freitas, Ana L. P.Seaweeds are the most abundant source of polysaccharides such as alginates and agar, as well as carrageenans. This study aimed to investigate the gastroprotective activity and the mechanism underlying this activity of a sulfated-polysaccharide fraction extracted from the algae Hypnea musciformis (Wulfen) J.V. Lamour. (Gigartinales– Rhodophyta). Mice were treated with sulfated-polysaccharide fraction (3, 10, 30,...
The hydrogen sulfide donor, Lawesson’s reagent, prevents alendronate-induced ga...
Nicolau, Lucas Antonio Duarte; Silva, R.O.; Damasceno, Samara Rodrigues Bonfim; Carvalho, N.S.; Costa, N.R.D.; Aragão, Karoline Sabóia; Barbosa, A.L.R.Our objective was to investigate the protective effect of Lawesson’s reagent, an H2S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or Lawesson’s reagent (3, 9, or 27 mmol/kg, po) once daily for 4 days. After 30 min, gastric damage was induced by ALD (30 mg/kg) administration by gavage. On the last day of treatment, the animals were killed 4 h after ALD adminis...