6 documents found, page 1 of 1
Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials
Das, G; Shin, HS; Leyva-Gómez, G; Prado-Audelo, MLD; Cortes, H; Singh, YD; Panda, MK; Mishra, AP; Nigam, M; Saklani, S; Chaturi, PK; Martorell, MIn recent decades, interest in the Cordyceps genus has amplified due to its immunostimulatory potential. Cordyceps species, its extracts, and bioactive constituents have been related with cytokine production such as interleukin (IL)-1ß, IL-2, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor (TNF)-a, phagocytosis stimulation of immune cells, nitric oxide production by increasing inducible nitric oxide synthas...
Phytosterols: From Preclinical Evidence to Potential Clinical Applications
Salehi, B; Quispe, C; Sharifi-Rad, J; Martins, N; Nigam, M; Mishra, AP; Konovalov, DA; Orobinskaya, V; Abu-Reidah, IM; Zam, W; Sharopov, F; Venneri, TPhytosterols (PSs) are plant-originated steroids. Over 250 PSs have been isolated, and each plant species contains a characteristic phytosterol composition. A wide number of studies have reported remarkable pharmacological effects of PSs, acting as chemopreventive, anti-inflammatory, antioxidant, antidiabetic, and antiatherosclerotic agents. However, PS bioavailability is a key issue, as it can be influenced by...
Plant-derived bioactives and oxidative stress-related disorders: A key trend to...
Salehi, B; Azzini, E; Zucca, P; Varoni, EM; Kumar, NVA; Dini, L; Panzarini, E; Rajkovic, J; Fokou, PVT; Peluso, I; Mishra, AP; Nigam, M; Rayess, YEPlants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hu...
Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysi...
Sharifi-Rad, M; Anil Kumar, NV; Zucca, P; Varoni, EM; Dini, L; Panzarini, E; Rajkovic, J; Tsouh Fokou, PV; Azzini, E; Peluso, I; Prakash Mishra, AOxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern...
Current trends on seaweeds: Looking at chemical composition, phytopharmacology,...
Salehi, B; Sharifi-Rad, J; Seca, AML; Pinto, DCGA; Michalak, I; Trincone, A; Mishra, AP; Nigam, M; Zam, W; Martins, NSeaweeds have received huge interest in recent years given their promising potentialities. Their antioxidant, anti-inflammatory, antitumor, hypolipemic, and anticoagulant effects are among the most renowned and studied bioactivities so far, and these effects have been increasingly associated with their content and richness in both primary and secondary metabolites. Although primary metabolites have a pivotal im...
Resveratrol: A double-edged sword in health benefits
Salehi, B; Mishra, A; Nigam, M; Sener, B; Kilic, M; Sharifi-Rad, M; Fokou, P; Martins, N; Sharifi-Rad, JResveratrol (3,5,4'-trihydroxy-trans-stilbene) belongs to polyphenols' stilbenoids group, possessing two phenol rings linked to each other by an ethylene bridge. This natural polyphenol has been detected inmore than 70 plant species, especially in grapes' skin and seeds, and was found in discrete amounts in red wines and various human foods. It is a phytoalexin that acts against pathogens, including bacteria an...